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A randomized comparison of different hormone replacement protocols for thawed blastocyst transfer

Sagiri Taguchi, Miyako Funabiki, Yoshihiro Tada, Masako Karita, Terumi Hayashi, Yoshitaka Nakamura
doi: https://doi.org/10.1101/114538
Sagiri Taguchi
1All authors address: Oak Clinic, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Miyako Funabiki
1All authors address: Oak Clinic, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Yoshihiro Tada
1All authors address: Oak Clinic, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Masako Karita
1All authors address: Oak Clinic, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Terumi Hayashi
1All authors address: Oak Clinic, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Yoshitaka Nakamura
1All authors address: Oak Clinic, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Abstract

Background There are no randomized controlled trials evaluating the pregnancy rates after thawed blastocyst transfers in patients treated with various hormone replacement regimens.

Methods A prospective randomized controlled trial was conducted to evaluate the outcomes in three different hormone replacement protocols for thawed blastocyst transfer. A total of 330 women (median age 38.2 years) who were undergoing IVF at our clinic were enrolled.

Results Serum estradiol (E2) levels were 267.71 pg/ml in Premarin group, 391.22 pg/ml in Estrogel group and 495.12 pg/ml in Estrana tape group. Therefore, serum E2 levels in Estrana tape group were higher than those of the other two groups (P<0.01). The pregnancy rate in the Estrogel group was higher than that in the Premarin group (30.0% versus 17.3%, P=0.026, odds ratio 2.05, 95% confidence interval: 1.09–3.87). Furthermore, the pregnancy rate in the Estrana tape group was higher than that in the Estrogel group (43.6% versus 30.0%, P=0.036, odds ratio 1.81, 95% confidence interval: 1.04–3.14).

Conclusion The serum E2 levels contributed to differences observed in the pregnancy rate among the three different protocols. Thus, Estrana tape has an advantage as a hormone replacement protocol for thawed blastocyst transfer.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted March 07, 2017.
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A randomized comparison of different hormone replacement protocols for thawed blastocyst transfer
Sagiri Taguchi, Miyako Funabiki, Yoshihiro Tada, Masako Karita, Terumi Hayashi, Yoshitaka Nakamura
bioRxiv 114538; doi: https://doi.org/10.1101/114538
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A randomized comparison of different hormone replacement protocols for thawed blastocyst transfer
Sagiri Taguchi, Miyako Funabiki, Yoshihiro Tada, Masako Karita, Terumi Hayashi, Yoshitaka Nakamura
bioRxiv 114538; doi: https://doi.org/10.1101/114538

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