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Psychiatric Genomics: An Update and an Agenda

View ORCID ProfilePatrick F Sullivan, View ORCID ProfileArpana Agrawal, View ORCID ProfileCynthia M Bulik, View ORCID ProfileOle A Andreassen, View ORCID ProfileAnders D Børglum, View ORCID ProfileGerome Breen, View ORCID ProfileSven Cichon, View ORCID ProfileHoward J Edenberg, Stephen V Faraone, View ORCID ProfileJoel Gelernter, View ORCID ProfileCarol A Mathews, Caroline M Nievergelt, View ORCID ProfileJordan Smoller, View ORCID ProfileMichael C O’Donovan, for the Psychiatric Genomics Consortium
doi: https://doi.org/10.1101/115600
Patrick F Sullivan
1Department of Medical Epidemiology and Biostatistics, Karolinska Institute, SE-17177 Stockholm, Sweden
2Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA
3Department of Psychiatry, University of North Carolina, Chapel Hill, NC, 27599, USA
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  • For correspondence: pfsulliv@med.unc.edu
Arpana Agrawal
4Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
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Cynthia M Bulik
1Department of Medical Epidemiology and Biostatistics, Karolinska Institute, SE-17177 Stockholm, Sweden
3Department of Psychiatry, University of North Carolina, Chapel Hill, NC, 27599, USA
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Ole A Andreassen
5NORMENT KG Jebsen Centre, University of Oslo and Oslo University Hospital, 0407 Oslo, Norway
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Anders D Børglum
6The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; Center for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark; Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark
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Gerome Breen
7King’s College London, Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK; National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, London, UK
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Sven Cichon
8Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland; Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, Bonn, Germany; Institute of Neuroscience and Medicine (INM-1), Juelich, Germany
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Howard J Edenberg
9Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA
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Stephen V Faraone
10Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse NY, USA; K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway
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Joel Gelernter
11Department of Psychiatry, Yale University, New Haven, CT, 06516, USA
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Carol A Mathews
12Department of Psychiatry and UF Genetics Institute, University of Florida, Gainesville, FL, 32611, USA
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Caroline M Nievergelt
13Department of Psychiatry, University of California, San Diego, La Jolla, CA, 92093, USA
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Jordan Smoller
14Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
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Michael C O’Donovan
15MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK
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Abstract

The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. In the past decade, this global effort has delivered a rapidly increasing flow of new knowledge about the fundamental basis of common psychiatric disorders, particularly given its dedication to rapid progress and open science. The PGC has recently commenced a program of research designed to deliver “actionable” findings - genomic results that (a) reveal the fundamental biology, (b) inform clinical practice, and (c) deliver new therapeutic targets. This is the central idea of the PGC: to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. The emerging findings suggest that we are entering into a phase of accelerated translation of genetic discoveries to impact psychiatric practice within a precision medicine framework.

Collaborators PGC Coordinating Committee: Mark Daly, Michael Gill, John Kelsoe, Karestan Koenen, Douglas Levinson, Cathryn Lewis, Ben Neale, Danielle Posthuma, Jonathan Sebat, and Pamela Sklar.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted March 10, 2017.
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Psychiatric Genomics: An Update and an Agenda
Patrick F Sullivan, Arpana Agrawal, Cynthia M Bulik, Ole A Andreassen, Anders D Børglum, Gerome Breen, Sven Cichon, Howard J Edenberg, Stephen V Faraone, Joel Gelernter, Carol A Mathews, Caroline M Nievergelt, Jordan Smoller, Michael C O’Donovan, for the Psychiatric Genomics Consortium
bioRxiv 115600; doi: https://doi.org/10.1101/115600
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Psychiatric Genomics: An Update and an Agenda
Patrick F Sullivan, Arpana Agrawal, Cynthia M Bulik, Ole A Andreassen, Anders D Børglum, Gerome Breen, Sven Cichon, Howard J Edenberg, Stephen V Faraone, Joel Gelernter, Carol A Mathews, Caroline M Nievergelt, Jordan Smoller, Michael C O’Donovan, for the Psychiatric Genomics Consortium
bioRxiv 115600; doi: https://doi.org/10.1101/115600

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