New mutations, old statistical challenges

Jeffrey C. Barrett; Joseph D. Buxbaum; David J. Cutler; Mark J. Daly; Bernie Devlin; Jacob Gratten; Matthew E. Hurles; Jack A. Kosmicki; Eric S. Lander; Daniel G. MacArthur; Benjamin M. Neale; Kathryn Roeder; Peter M. Visscher; Naomi R. Wray

doi:10.1101/115964

Contradictory Results

New mutations, old statistical challenges

Jeffrey C. Barrett, Joseph D. Buxbaum, David J. Cutler, Mark J. Daly, Bernie Devlin, Jacob Gratten, Matthew E. Hurles, Jack A. Kosmicki, Eric S. Lander, Daniel G. MacArthur, Benjamin M. Neale, Kathryn Roeder, Peter M. Visscher, Naomi R. Wray

doi: https://doi.org/10.1101/115964

Jeffrey C. Barrett

1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, UK

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Joseph D. Buxbaum

2Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

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David J. Cutler

3Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA

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Mark J. Daly

4Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

5Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA

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Bernie Devlin

6Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA

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Jacob Gratten

7Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia

8Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia

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Matthew E. Hurles

1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, UK

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Jack A. Kosmicki

4Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

5Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA

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Eric S. Lander

5Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA

9Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

10Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA

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Daniel G. MacArthur

4Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

5Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA

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Benjamin M. Neale

4Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

5Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA

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Kathryn Roeder

11Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA

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Peter M. Visscher

8Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia

12The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane, QLD 4102, Australia

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Naomi R. Wray

8Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia

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