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HUGIn: Hi-C Unifying Genomic Interrogator

Joshua S. Martin, Zheng Xu, Alex P. Reiner, Karen L. Mohlke, Patrick Sullivan, Bing Ren, Ming Hu, Yun Li
doi: https://doi.org/10.1101/117531
Joshua S. Martin
1Department of Genetics
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Zheng Xu
4Department of Statistics, University of Nebraska, Lincoln, NE 68583, USA
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Alex P. Reiner
5Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
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Karen L. Mohlke
1Department of Genetics
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Patrick Sullivan
1Department of Genetics
6Department of Medical Epidemiology and Biostatistics, Karolinksa Institutet, Stockholm, Sweden
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Bing Ren
7University of California, San Diego School of Medicine, Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, UCSD Moores Cancer Center, 9500 Gilman Drive, La Jolla, California 92093, USA
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Ming Hu
8Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
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Yun Li
1Department of Genetics
2Department of Biostatistics
3Department of Computer Science, University of North Carolina, Chapel Hill NC 27599, USA
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Abstract

Motivation High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChlA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.

Results We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell liens. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTLs results and functional genomics data.

Availability HUGIn is available at http://yunliweb.its.unc.edu/HUGIn.

Contact yunli{at}med.unc.edu and hum{at}ccf.org

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Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted March 16, 2017.
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HUGIn: Hi-C Unifying Genomic Interrogator
Joshua S. Martin, Zheng Xu, Alex P. Reiner, Karen L. Mohlke, Patrick Sullivan, Bing Ren, Ming Hu, Yun Li
bioRxiv 117531; doi: https://doi.org/10.1101/117531
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HUGIn: Hi-C Unifying Genomic Interrogator
Joshua S. Martin, Zheng Xu, Alex P. Reiner, Karen L. Mohlke, Patrick Sullivan, Bing Ren, Ming Hu, Yun Li
bioRxiv 117531; doi: https://doi.org/10.1101/117531

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