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Discovering in vivo cytokine eQTL interactions from a lupus clinical trial
View ORCID ProfileEmma E. Davenport, Tiffany Amariuta, Maria Gutierrez-Arcelus, Kamil Slowikowski, Harm-Jan Westra, Yang Luo, Ciyue Shen, Deepak A. Rao, Ying Zhang, Stephen Pearson, David von Schack, Jean S. Beebe, Nan Bing, Sally John, Michael S. Vincent, Baohong Zhang, Soumya Raychaudhuri
doi: https://doi.org/10.1101/118703
Emma E. Davenport
1Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA, 02115, USA.
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA.
3Partners Center for Personalized Genetic Medicine, Boston, MA, 02115, USA.
4Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Tiffany Amariuta
1Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA, 02115, USA.
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA.
3Partners Center for Personalized Genetic Medicine, Boston, MA, 02115, USA.
4Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
5Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA.
Maria Gutierrez-Arcelus
1Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA, 02115, USA.
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA.
3Partners Center for Personalized Genetic Medicine, Boston, MA, 02115, USA.
4Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Kamil Slowikowski
1Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA, 02115, USA.
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA.
3Partners Center for Personalized Genetic Medicine, Boston, MA, 02115, USA.
4Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
5Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA.
Harm-Jan Westra
1Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA, 02115, USA.
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA.
3Partners Center for Personalized Genetic Medicine, Boston, MA, 02115, USA.
4Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Yang Luo
1Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA, 02115, USA.
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA.
3Partners Center for Personalized Genetic Medicine, Boston, MA, 02115, USA.
4Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Ciyue Shen
6Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA
Deepak A. Rao
7Division of Rheumatology, Allergy, Immunology, Brigham and Women’s Hospital, Harvard Medical School, MA 02115, USA.
Ying Zhang
8Pfizer Inc., Cambridge, MA, 02139, USA.
Stephen Pearson
9Pfizer New Haven Clinical Research Unit, New Haven, CT, 06511, USA.
David von Schack
8Pfizer Inc., Cambridge, MA, 02139, USA.
Jean S. Beebe
8Pfizer Inc., Cambridge, MA, 02139, USA.
Nan Bing
8Pfizer Inc., Cambridge, MA, 02139, USA.
Sally John
10Biogen, Cambridge, MA, 02142, USA.
Michael S. Vincent
8Pfizer Inc., Cambridge, MA, 02139, USA.
Baohong Zhang
8Pfizer Inc., Cambridge, MA, 02139, USA.
Soumya Raychaudhuri
1Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA, 02115, USA.
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA.
3Partners Center for Personalized Genetic Medicine, Boston, MA, 02115, USA.
4Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
5Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA.
11Faculty of Medical and Human Sciences, University of Manchester, Manchester, M13 9PL, UK.
Article usage
Posted February 20, 2018.
Discovering in vivo cytokine eQTL interactions from a lupus clinical trial
Emma E. Davenport, Tiffany Amariuta, Maria Gutierrez-Arcelus, Kamil Slowikowski, Harm-Jan Westra, Yang Luo, Ciyue Shen, Deepak A. Rao, Ying Zhang, Stephen Pearson, David von Schack, Jean S. Beebe, Nan Bing, Sally John, Michael S. Vincent, Baohong Zhang, Soumya Raychaudhuri
bioRxiv 118703; doi: https://doi.org/10.1101/118703
Discovering in vivo cytokine eQTL interactions from a lupus clinical trial
Emma E. Davenport, Tiffany Amariuta, Maria Gutierrez-Arcelus, Kamil Slowikowski, Harm-Jan Westra, Yang Luo, Ciyue Shen, Deepak A. Rao, Ying Zhang, Stephen Pearson, David von Schack, Jean S. Beebe, Nan Bing, Sally John, Michael S. Vincent, Baohong Zhang, Soumya Raychaudhuri
bioRxiv 118703; doi: https://doi.org/10.1101/118703
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