Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

MTAG: Multi-Trait Analysis of GWAS

Patrick Turley, Raymond K. Walters, Omeed Maghzian, Aysu Okbay, James J. Lee, Mark Alan Fontana, Tuan Anh Nguyen-Viet, Nicholas A. Furlotte, 23andMe Research Team, Social Science Genetic Association Consortium, Patrik Magnusson, Sven Oskarsson, Magnus Johannesson, Peter M. Visscher, David Laibson, David Cesarini, Benjamin Neale, Daniel J. Benjamin
doi: https://doi.org/10.1101/118810
Patrick Turley
1Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States
2Analytic and Translational Genetics Unit, Massachusetts General Hospital, 185 Cambridge Street, Cambridge, Massachusetts 02114, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raymond K. Walters
1Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States
2Analytic and Translational Genetics Unit, Massachusetts General Hospital, 185 Cambridge Street, Cambridge, Massachusetts 02114, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Omeed Maghzian
3Department of Economics, Harvard University, 1805 Cambridge Street, Cambridge, Massachusetts 02138, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aysu Okbay
4Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, De Boelelaan 1085, Amsterdam, 1081 HV, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James J. Lee
5Department of Psychology, University of Minnesota, 75 E River Road, Minneapolis, Minnesota 55455, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark Alan Fontana
6Hospital for Special Surgery, 535 E 70th Street, New York, New York 10021, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tuan Anh Nguyen-Viet
7Center for Economic and Social Research, University of Southern California, 635 Downey Way, Los Angeles, California 90089, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nicholas A. Furlotte
823andMe, Inc., Mountain View, California 94043, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
823andMe, Inc., Mountain View, California 94043, United States
Patrik Magnusson
9Institutionen för Medicinsk Epidemiologi och Biostatistik, Karolinska Institutet, 171 77 Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sven Oskarsson
10Department of Government, Uppsala Universitet, 751 20 Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Magnus Johannesson
11Department of Economics, Stockholm School of Economics, 113 83 Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter M. Visscher
12Institute for Molecular Bioscience, The University of Queensland, Building 80 Services Road, QLD 4072, Brisbane, Queensland, Australia
13Queensland Brain Institute, The University of Queensland, Building 79 Services Road, QLD 4072, Brisbane, Queensland, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Laibson
3Department of Economics, Harvard University, 1805 Cambridge Street, Cambridge, Massachusetts 02138, United States
14National Bureau of Economic Research, 1050 Massachusetts Avenue, Cambridge, Massachusetts 02138, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Cesarini
14National Bureau of Economic Research, 1050 Massachusetts Avenue, Cambridge, Massachusetts 02138, United States
15Department of Economics and Center for Experimental Social Science, New York University, 19 W 4th Street, New York, New York 10012, United States
16Institutet för Näringslivsforskning, 114 53 Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: paturley@broadinstitute.org bneale@broadinstitute.org dac12@nyu.edu daniel.benjamin@gmail.com
Benjamin Neale
1Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States
2Analytic and Translational Genetics Unit, Massachusetts General Hospital, 185 Cambridge Street, Cambridge, Massachusetts 02114, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: paturley@broadinstitute.org bneale@broadinstitute.org dac12@nyu.edu daniel.benjamin@gmail.com
Daniel J. Benjamin
7Center for Economic and Social Research, University of Southern California, 635 Downey Way, Los Angeles, California 90089, United States
14National Bureau of Economic Research, 1050 Massachusetts Avenue, Cambridge, Massachusetts 02138, United States
17Department of Economics, University of Southern California, 3620 South Vermont Avenue, Kaprielian Hall, 300 Los Angeles, CA 90089, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: paturley@broadinstitute.org bneale@broadinstitute.org dac12@nyu.edu daniel.benjamin@gmail.com
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

ABSTRACT

We introduce Multi-Trait Analysis of GWAS (MTAG), a method for the joint analysis of summary statistics from GWASs of different traits, possibly from overlapping samples. We demonstrate MTAG using data on depressive symptoms (Neff = 354,862), neuroticism (N = 168,105), and subjective well-being (N = 388,538). Compared to 32, 9, and 13 genome-wide significant loci in the single-trait GWASs (most of which are novel), MTAG increases the number of loci to 74, 66, and 60, respectively. Moreover, the association statistics from MTAG yield more informative bioinformatics analyses and, consistent with theoretical calculations, improve prediction accuracy by approximately 25%.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted March 20, 2017.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
MTAG: Multi-Trait Analysis of GWAS
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
MTAG: Multi-Trait Analysis of GWAS
Patrick Turley, Raymond K. Walters, Omeed Maghzian, Aysu Okbay, James J. Lee, Mark Alan Fontana, Tuan Anh Nguyen-Viet, Nicholas A. Furlotte, 23andMe Research Team, Social Science Genetic Association Consortium, Patrik Magnusson, Sven Oskarsson, Magnus Johannesson, Peter M. Visscher, David Laibson, David Cesarini, Benjamin Neale, Daniel J. Benjamin
bioRxiv 118810; doi: https://doi.org/10.1101/118810
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
MTAG: Multi-Trait Analysis of GWAS
Patrick Turley, Raymond K. Walters, Omeed Maghzian, Aysu Okbay, James J. Lee, Mark Alan Fontana, Tuan Anh Nguyen-Viet, Nicholas A. Furlotte, 23andMe Research Team, Social Science Genetic Association Consortium, Patrik Magnusson, Sven Oskarsson, Magnus Johannesson, Peter M. Visscher, David Laibson, David Cesarini, Benjamin Neale, Daniel J. Benjamin
bioRxiv 118810; doi: https://doi.org/10.1101/118810

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Genomics
Subject Areas
All Articles
  • Animal Behavior and Cognition (2430)
  • Biochemistry (4791)
  • Bioengineering (3332)
  • Bioinformatics (14677)
  • Biophysics (6639)
  • Cancer Biology (5168)
  • Cell Biology (7428)
  • Clinical Trials (138)
  • Developmental Biology (4365)
  • Ecology (6873)
  • Epidemiology (2057)
  • Evolutionary Biology (9919)
  • Genetics (7346)
  • Genomics (9527)
  • Immunology (4554)
  • Microbiology (12684)
  • Molecular Biology (4945)
  • Neuroscience (28329)
  • Paleontology (199)
  • Pathology (808)
  • Pharmacology and Toxicology (1391)
  • Physiology (2024)
  • Plant Biology (4498)
  • Scientific Communication and Education (977)
  • Synthetic Biology (1299)
  • Systems Biology (3914)
  • Zoology (726)