Abstract
Epistasis and genetic variance heterogeneity are two non-additive genetic inheritance patterns that are often, but not always, related. Here we use theoretical examples and empirical results from analyses of experimental data to illustrate the connection between the two. This includes an introduction to the relationship between epistatic gene-action, statistical epistasis and genetic variance heterogeneity and a brief discussion about how other genetic processes than epistasis can also give rise to genetic variance heterogeneity.
Highlight Genetic effects on the trait variance, rather than the mean, have been found in several studies. Here we discuss how this sometimes, but not always, can be caused by epistasis.
Abbreviations
- GP-space
- Genotype to Phenotype space
- QTL
- Quantitative Trait Locus
- GWA
- Genome Wide Association
- H2
- Broad sense heritability
- h2
- Narrow sense heritability
- LD
- Linkage Disequilibrium
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted March 23, 2017.
