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On the relationship between epistasis and genetic variance-heterogeneity

View ORCID ProfileSimon Forsberg, View ORCID ProfileÖrjan Carlborg
doi: https://doi.org/10.1101/119727
Simon Forsberg
1department of Medical Biochemistry and Microbiology, Uppsala University, Box 598, SE-75123 Uppsala, Sweden
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Örjan Carlborg
1department of Medical Biochemistry and Microbiology, Uppsala University, Box 598, SE-75123 Uppsala, Sweden
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  • For correspondence: simon.forsberg@imbim.uu.se orjan.carlborg@imbim.uu.se
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Abstract

Epistasis and genetic variance heterogeneity are two non-additive genetic inheritance patterns that are often, but not always, related. Here we use theoretical examples and empirical results from analyses of experimental data to illustrate the connection between the two. This includes an introduction to the relationship between epistatic gene-action, statistical epistasis and genetic variance heterogeneity and a brief discussion about how other genetic processes than epistasis can also give rise to genetic variance heterogeneity.

Highlight Genetic effects on the trait variance, rather than the mean, have been found in several studies. Here we discuss how this sometimes, but not always, can be caused by epistasis.

  • Abbreviations

    GP-space
    Genotype to Phenotype space
    QTL
    Quantitative Trait Locus
    GWA
    Genome Wide Association
    H2
    Broad sense heritability
    h2
    Narrow sense heritability
    LD
    Linkage Disequilibrium
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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    Posted March 23, 2017.
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    On the relationship between epistasis and genetic variance-heterogeneity
    Simon Forsberg, Örjan Carlborg
    bioRxiv 119727; doi: https://doi.org/10.1101/119727
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    On the relationship between epistasis and genetic variance-heterogeneity
    Simon Forsberg, Örjan Carlborg
    bioRxiv 119727; doi: https://doi.org/10.1101/119727

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