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Transient network synchrony of the developing medial entorhinal cortex

Julia Dawitz, J.J. Johannes Hjorth, Tim Kroon, Marta Ruiperez-Alonso, Nandakumar Chandrasekhar, Henrike Hartung, Ileana L. Hanganu-Opatz, Huibert D. Mansvelder, View ORCID ProfileRhiannon M. Meredith
doi: https://doi.org/10.1101/121459
Julia Dawitz
1Department of Integrative Neurophysiology, Center for Neurogenomics & Cognitive Research, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.
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J.J. Johannes Hjorth
1Department of Integrative Neurophysiology, Center for Neurogenomics & Cognitive Research, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.
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Tim Kroon
1Department of Integrative Neurophysiology, Center for Neurogenomics & Cognitive Research, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.
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Marta Ruiperez-Alonso
1Department of Integrative Neurophysiology, Center for Neurogenomics & Cognitive Research, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.
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Nandakumar Chandrasekhar
1Department of Integrative Neurophysiology, Center for Neurogenomics & Cognitive Research, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.
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Henrike Hartung
2Developmental Neurophysiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
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Ileana L. Hanganu-Opatz
2Developmental Neurophysiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
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Huibert D. Mansvelder
1Department of Integrative Neurophysiology, Center for Neurogenomics & Cognitive Research, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.
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Rhiannon M. Meredith
1Department of Integrative Neurophysiology, Center for Neurogenomics & Cognitive Research, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.
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  • ORCID record for Rhiannon M. Meredith
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Abstract

The medial entorhinal cortex (MEC) contains a variety of specialized spatially-tuned neurons whose properties emerge during the third postnatal week onwards in rodents. How neuronal networks underlying the spatial firing patterns are formed is largely unknown but they are hypothesized to develop from topographic modules of synchronized neurons in superficial MEC. Here, we show that developing MEC neuronal networks in the second postnatal week are synchronously active in spatially-grouped modules. Network synchrony is intrinsic to MEC and desynchronized just prior to the emergence of spatially-tuned firing properties. The MEC network is modulated but not driven by the immature hippocampus and is tightly-coupled to neighboring neocortical networks. Unlike hippocampal networks, developing modules are dominated by glutamatergic excitation rather than GABAergic inhibition. Our results demonstrate that intrinsically synchronous modules exist in immature MEC: these may play a key role in establishing and organizing circuitry necessary for spatially-tuned firing properties of MEC neurons.

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Posted March 28, 2017.
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Transient network synchrony of the developing medial entorhinal cortex
Julia Dawitz, J.J. Johannes Hjorth, Tim Kroon, Marta Ruiperez-Alonso, Nandakumar Chandrasekhar, Henrike Hartung, Ileana L. Hanganu-Opatz, Huibert D. Mansvelder, Rhiannon M. Meredith
bioRxiv 121459; doi: https://doi.org/10.1101/121459
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Transient network synchrony of the developing medial entorhinal cortex
Julia Dawitz, J.J. Johannes Hjorth, Tim Kroon, Marta Ruiperez-Alonso, Nandakumar Chandrasekhar, Henrike Hartung, Ileana L. Hanganu-Opatz, Huibert D. Mansvelder, Rhiannon M. Meredith
bioRxiv 121459; doi: https://doi.org/10.1101/121459

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