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Tissue adaptation: implications for gut immunity and tolerance

Ana M. C. Faria, Bernardo S. Reis, Daniel Mucida
doi: https://doi.org/10.1101/125641
Ana M. C. Faria
1Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
2Permanent position: Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270901, Brazil.
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Bernardo S. Reis
1Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
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Daniel Mucida
1Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
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Abstract

Tissue adaptation is an intrinsic component of immune cell development, influencing both resistance to pathogens and tolerance. Chronically stimulated surfaces of the body, in particular the gut mucosa, are the major sites where immune cells traffic and reside. Their adaptation to these environments requires constant discrimination between natural stimulation coming from harmless microbiota and food, and pathogens that need to be cleared. This review will focus on the adaptation of lymphocytes to the gut mucosa, a highly specialized environment that can help us understand the plasticity of leukocytes arriving at various tissue sites and how tissue-related factors operate to shape immune cell fate and function.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 08, 2017.
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Tissue adaptation: implications for gut immunity and tolerance
Ana M. C. Faria, Bernardo S. Reis, Daniel Mucida
bioRxiv 125641; doi: https://doi.org/10.1101/125641
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Tissue adaptation: implications for gut immunity and tolerance
Ana M. C. Faria, Bernardo S. Reis, Daniel Mucida
bioRxiv 125641; doi: https://doi.org/10.1101/125641

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