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Single Cell Transcriptomics and Flow Cytometry Reveal Disease-associated Fibroblast Subsets in Rheumatoid Arthritis
Fumitaka Mizoguchi, Kamil Slowikowski, Jennifer L Marshall, Kevin Wei, Deepak A Rao, Sook Kyung Chang, Hung N Nguyen, Erika H Noss, Jason D Turner, Brandon E Earp, Philip E Blazar, John Wright, Barry P Simmons, Laura T Donlin, George D Kalliolias, Susan M Goodman, Vivian P Bykerk, Lionel B Ivashkiv, James A Lederer, Nir Hacohen, Peter A Nigrovic, Andrew Filer, Christopher D Buckley, Soumya Raychaudhuri, Michael B Brenner
doi: https://doi.org/10.1101/126193
Fumitaka Mizoguchi
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Kamil Slowikowski
2Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02446, USA
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Bioinformatics and Integrative Genomics, Harvard University, Cambridge, MA 02138, USA
5Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA
Jennifer L Marshall
6Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WB, UK
Kevin Wei
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Deepak A Rao
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Sook Kyung Chang
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Hung N Nguyen
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Erika H Noss
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Jason D Turner
6Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WB, UK
Brandon E Earp
7Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA
Philip E Blazar
7Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA
John Wright
7Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA
Barry P Simmons
7Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA
Laura T Donlin
8Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA
9Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA
George D Kalliolias
8Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA
Susan M Goodman
8Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA
9Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA
Vivian P Bykerk
8Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA
9Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA
Lionel B Ivashkiv
8Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA
9Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA
James A Lederer
10Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Nir Hacohen
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
11Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02114, USA
12Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Peter A Nigrovic
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
13Division of Immunology, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
Andrew Filer
6Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WB, UK
Christopher D Buckley
6Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WB, UK
Soumya Raychaudhuri
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
2Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02446, USA
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA
14Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK
Michael B Brenner
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Article usage
Posted May 26, 2017.
Single Cell Transcriptomics and Flow Cytometry Reveal Disease-associated Fibroblast Subsets in Rheumatoid Arthritis
Fumitaka Mizoguchi, Kamil Slowikowski, Jennifer L Marshall, Kevin Wei, Deepak A Rao, Sook Kyung Chang, Hung N Nguyen, Erika H Noss, Jason D Turner, Brandon E Earp, Philip E Blazar, John Wright, Barry P Simmons, Laura T Donlin, George D Kalliolias, Susan M Goodman, Vivian P Bykerk, Lionel B Ivashkiv, James A Lederer, Nir Hacohen, Peter A Nigrovic, Andrew Filer, Christopher D Buckley, Soumya Raychaudhuri, Michael B Brenner
bioRxiv 126193; doi: https://doi.org/10.1101/126193
Single Cell Transcriptomics and Flow Cytometry Reveal Disease-associated Fibroblast Subsets in Rheumatoid Arthritis
Fumitaka Mizoguchi, Kamil Slowikowski, Jennifer L Marshall, Kevin Wei, Deepak A Rao, Sook Kyung Chang, Hung N Nguyen, Erika H Noss, Jason D Turner, Brandon E Earp, Philip E Blazar, John Wright, Barry P Simmons, Laura T Donlin, George D Kalliolias, Susan M Goodman, Vivian P Bykerk, Lionel B Ivashkiv, James A Lederer, Nir Hacohen, Peter A Nigrovic, Andrew Filer, Christopher D Buckley, Soumya Raychaudhuri, Michael B Brenner
bioRxiv 126193; doi: https://doi.org/10.1101/126193
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