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Cell type boundaries organize plant development

Monica Pia Caggiano, Xiulian Yu, Neha Bhatia, André Larsson, Hasthi Ram, Carolyn Ohno, Pia Sappl, View ORCID ProfileElliot M. Meyerowitz, Henrik Jönsson, View ORCID ProfileMarcus G. Heisler
doi: https://doi.org/10.1101/126466
Monica Pia Caggiano
1European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
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Xiulian Yu
1European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
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Neha Bhatia
1European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
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André Larsson
2Computational Biology and Biological Physics, Department of Astronomy and Theoretical Physics, Lund University, Sweden
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Hasthi Ram
1European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
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Carolyn Ohno
1European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
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Pia Sappl
1European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
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Elliot M. Meyerowitz
3Division of Biology and Biological Engineering and Howard Hughes Medical Institute, 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
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Henrik Jönsson
2Computational Biology and Biological Physics, Department of Astronomy and Theoretical Physics, Lund University, Sweden
4Sainsbury Laboratory, University of Cambridge, Cambridge, UK
5Department of Applied Mathematics and Theoretical Physics, University of Cambridge, UK
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Marcus G. Heisler
1European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
6School of Life and Environmental Sciences, University of Sydney, NSW, Australia
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  • ORCID record for Marcus G. Heisler
  • For correspondence: marcus.heisler@sydney.edu.au
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Abstract

In plants the dorsoventral boundary of leaves defines an axis of symmetry through the centre of the organ separating the top (dorsal) and bottom (ventral) tissues. Although the positioning of this boundary is critical for leaf morphogenesis, how the boundary is established and how it influences development remains unclear. Using live-imaging and perturbation experiments we show that leaf orientation, morphology and position are pre-patterned by HD-ZIPIII and KAN gene expression in the shoot, leading to a model in which dorsoventral genes coordinate to regulate plant development by localizing auxin response between their expression domains. However we also find that auxin levels feedback on dorsoventral patterning by spatially organizing HD-ZIPIII and KAN expression in the shoot periphery. By demonstrating that the regulation of these genes by auxin also governs their response to wounds, our results also provide a parsimonious explanation for the influence of wounds on leaf dorsoventrality.

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Posted June 12, 2017.
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Cell type boundaries organize plant development
Monica Pia Caggiano, Xiulian Yu, Neha Bhatia, André Larsson, Hasthi Ram, Carolyn Ohno, Pia Sappl, Elliot M. Meyerowitz, Henrik Jönsson, Marcus G. Heisler
bioRxiv 126466; doi: https://doi.org/10.1101/126466
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Cell type boundaries organize plant development
Monica Pia Caggiano, Xiulian Yu, Neha Bhatia, André Larsson, Hasthi Ram, Carolyn Ohno, Pia Sappl, Elliot M. Meyerowitz, Henrik Jönsson, Marcus G. Heisler
bioRxiv 126466; doi: https://doi.org/10.1101/126466

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