Environmental cystine drives glutamine anaplerosis and sensitizes cells to glutaminase inhibition

Alexander Muir; Laura V. Danai; Dan Y. Gui; Chiara Y. Waingarten; Matthew G. Vander Heiden

doi:10.1101/126631

New Results

Environmental cystine drives glutamine anaplerosis and sensitizes cells to glutaminase inhibition

View ORCID ProfileAlexander Muir, View ORCID ProfileLaura V. Danai, Dan Y. Gui, Chiara Y. Waingarten, Matthew G. Vander Heiden

doi: https://doi.org/10.1101/126631

Alexander Muir

1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alexander Muir

Laura V. Danai

1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Laura V. Danai

Dan Y. Gui

1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Chiara Y. Waingarten

1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Matthew G. Vander Heiden

1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: mvh@mit.edu

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Figure 1 Source Data
Figure 1 Supplement 1 Source Data
Figure 1 Supplement 2 Source Data
Figure 2 Source Data
Figure 2 Supplement 1 Source Data
Figure 2 Source Data
Figure 4 Source Data
Figure 5 Source Data

View the discussion thread.

PreviousNext

Posted April 11, 2017.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Environmental cystine drives glutamine anaplerosis and sensitizes cells to glutaminase inhibition

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Environmental cystine drives glutamine anaplerosis and sensitizes cells to glutaminase inhibition

Alexander Muir, Laura V. Danai, Dan Y. Gui, Chiara Y. Waingarten, Matthew G. Vander Heiden

bioRxiv 126631; doi: https://doi.org/10.1101/126631

Share This Article:

Citation Tools

Environmental cystine drives glutamine anaplerosis and sensitizes cells to glutaminase inhibition

Alexander Muir, Laura V. Danai, Dan Y. Gui, Chiara Y. Waingarten, Matthew G. Vander Heiden

bioRxiv 126631; doi: https://doi.org/10.1101/126631

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Biochemistry

Subject Areas

All Articles

Animal Behavior and Cognition (4666)
Biochemistry (10324)
Bioengineering (7649)
Bioinformatics (26274)
Biophysics (13490)
Cancer Biology (10659)
Cell Biology (15386)
Clinical Trials (138)
Developmental Biology (8474)
Ecology (12795)
Epidemiology (2067)
Evolutionary Biology (16812)
Genetics (11377)
Genomics (15443)
Immunology (10589)
Microbiology (25112)
Molecular Biology (10183)
Neuroscience (54296)
Paleontology (399)
Pathology (1663)
Pharmacology and Toxicology (2888)
Physiology (4330)
Plant Biology (9221)
Scientific Communication and Education (1585)
Synthetic Biology (2548)
Systems Biology (6766)
Zoology (1459)