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Just above chance: is it harder to decode information from human prefrontal cortex BOLD signals?

Apoorva Bhandari, View ORCID ProfileChristopher Gagne, David Badre
doi: https://doi.org/10.1101/127324
Apoorva Bhandari
1Cognitive, Linguistic, & Psychological Sciences, Brown University, Providence, USA
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Christopher Gagne
2Department of Psychology, University of California Berkeley, Berkeley, USA
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David Badre
2Department of Psychology, University of California Berkeley, Berkeley, USA
3Brown Institute for Brain Science, Brown University, Providence, USA
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Abstract

Understanding the nature and form of prefrontal cortex representations that support flexible behavior is an important open problem in cognitive neuroscience. In humans, multi-voxel pattern analysis (MVPA) of fMRI BOLD measurements has emerged as an important approach for studying neural representations. An implicit, untested assumption underlying many PFC MVPA studies is that the base rate of decoding information from PFC BOLD activity patterns is similar to that of other brain regions. Here we estimate these base rates from a meta-analysis of published MVPA studies and show that the PFC has a significantly lower base rate for decoding than visual sensory cortex. Our results have implications for the design and interpretation of MVPA studies of prefrontal cortex, and raise important questions about its functional organization.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted June 16, 2017.
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Just above chance: is it harder to decode information from human prefrontal cortex BOLD signals?
Apoorva Bhandari, Christopher Gagne, David Badre
bioRxiv 127324; doi: https://doi.org/10.1101/127324
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Just above chance: is it harder to decode information from human prefrontal cortex BOLD signals?
Apoorva Bhandari, Christopher Gagne, David Badre
bioRxiv 127324; doi: https://doi.org/10.1101/127324

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