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Defects of myelination are common pathophysiology in syndromic and idiopathic autism spectrum disorder

View ORCID ProfileBaDoi N. Phan, Stephanie Cerceo Page, Morganne N. Campbell, Joseph F. Bohlen, Courtney L. Thaxton, Jeremy M. Simon, Emily E. Burke, Joo Heon Shin, Andrew J. Kennedy, J. David Sweatt, Benjamin D. Philpot, Andrew E. Jaffe, Brady J. Maher
doi: https://doi.org/10.1101/128124
BaDoi N. Phan
1Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD
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Stephanie Cerceo Page
1Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD
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Morganne N. Campbell
1Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD
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Joseph F. Bohlen
1Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD
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Courtney L. Thaxton
2Neuroscience Center, University of North Carolina, Chapel Hill, NC
3Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC
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Jeremy M. Simon
2Neuroscience Center, University of North Carolina, Chapel Hill, NC
4Department of Genetics, University of North Carolina, Chapel Hill, NC
5Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC
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Emily E. Burke
1Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD
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Joo Heon Shin
1Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD
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Andrew J. Kennedy
6Department of Chemistry, Bates College, Lewiston, ME
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J. David Sweatt
7Department of Pharmacology, Vanderbilt University, Nashville, TN
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Benjamin D. Philpot
2Neuroscience Center, University of North Carolina, Chapel Hill, NC
3Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC
5Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC
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Andrew E. Jaffe
1Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD
8Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
9Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
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  • For correspondence: Andrew.Jaffe@libd.org Brady.Maher@libd.org
Brady J. Maher
1Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD
10Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD
11Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD
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  • For correspondence: Andrew.Jaffe@libd.org Brady.Maher@libd.org
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Article Information

doi 
https://doi.org/10.1101/128124
History 
  • May 11, 2017.

Article Versions

  • Version 1 (April 18, 2017 - 12:26).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. BaDoi N. Phan1,
  2. Stephanie Cerceo Page1,
  3. Morganne N. Campbell1,
  4. Joseph F. Bohlen1,
  5. Courtney L. Thaxton2,3,
  6. Jeremy M. Simon2,4,5,
  7. Emily E. Burke1,
  8. Joo Heon Shin1,
  9. Andrew J. Kennedy6,
  10. J. David Sweatt7,
  11. Benjamin D. Philpot2,3,5,
  12. Andrew E. Jaffe1,8,9,* and
  13. Brady J. Maher1,10,11,*
  1. 1Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD
  2. 2Neuroscience Center, University of North Carolina, Chapel Hill, NC
  3. 3Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC
  4. 4Department of Genetics, University of North Carolina, Chapel Hill, NC
  5. 5Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC
  6. 6Department of Chemistry, Bates College, Lewiston, ME
  7. 7Department of Pharmacology, Vanderbilt University, Nashville, TN
  8. 8Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
  9. 9Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
  10. 10Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD
  11. 11Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD
  1. ↵*Correspondence to: Andrew.Jaffe{at}libd.org and Brady.Maher{at}libd.org
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Defects of myelination are common pathophysiology in syndromic and idiopathic autism spectrum disorder
BaDoi N. Phan, Stephanie Cerceo Page, Morganne N. Campbell, Joseph F. Bohlen, Courtney L. Thaxton, Jeremy M. Simon, Emily E. Burke, Joo Heon Shin, Andrew J. Kennedy, J. David Sweatt, Benjamin D. Philpot, Andrew E. Jaffe, Brady J. Maher
bioRxiv 128124; doi: https://doi.org/10.1101/128124
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Defects of myelination are common pathophysiology in syndromic and idiopathic autism spectrum disorder
BaDoi N. Phan, Stephanie Cerceo Page, Morganne N. Campbell, Joseph F. Bohlen, Courtney L. Thaxton, Jeremy M. Simon, Emily E. Burke, Joo Heon Shin, Andrew J. Kennedy, J. David Sweatt, Benjamin D. Philpot, Andrew E. Jaffe, Brady J. Maher
bioRxiv 128124; doi: https://doi.org/10.1101/128124

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