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Interpreting differentiation landscapes in the light of long-term linked selection

View ORCID ProfileReto Burri
doi: https://doi.org/10.1101/131243
Reto Burri
Department of Population Ecology, Friedrich Schiller University Jena, Dornburger Strasse 159, D-07743 Jena, Germany
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Abstract

Identifying genomic regions underlying adaptation in extant lineages is key to understand the trajectories along which biodiversity evolves. However, this task is complicated by evolutionary processes that obscure and mimic footprints of positive selection. Particularly the long-term effects of linked selection remain underappreciated and difficult to account for. Based on patterns emerging from recent research on the evolution of differentiation across the speciation continuum, I illustrate how long-term linked selection affects the distribution of differentiation along genomes. I then argue that a comparative population genomics framework that exploits emergent features of long-term linked selection can help overcome shortcomings of traditional genome scans for adaptive evolution, but needs to account for the temporal dynamics of differentiation landscapes.

  • Glossary

    Background selection
    A process by which purifying selection against deleterious variants results in a loss of neutral genetic diversity at linked sites.
    Extant lineages (extant populations, extant species)
    Non-ancestral lineages, i.e. lineages observed today including the time since the split from their ancestor.
    Genomic landscapes
    The distribution of parameters, such as diversity (‘diversity landscape’), differentiation (‘differentiation landscape’) or recombination rates (‘recombination landscape’) along chromosomes.
    Hitchhiking/recurrent hitchhiking
    A process by which positive selection for a beneficial variant leads to an increase in frequency of neutral variants at linked sites, and thus loss of neutral diversity at linked sites. If hitchhiking affects the same genomic region repeatedly, the process is referred to as recurrent hitchhiking.
    Linked selection
    The process by which neutral genetic diversity in the genome is lost as an effect of selection at a linked site. Both background selection and hitchhiking contribute to linked selection.
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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    Posted April 28, 2017.
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    Interpreting differentiation landscapes in the light of long-term linked selection
    Reto Burri
    bioRxiv 131243; doi: https://doi.org/10.1101/131243
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    Interpreting differentiation landscapes in the light of long-term linked selection
    Reto Burri
    bioRxiv 131243; doi: https://doi.org/10.1101/131243

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