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Altered expression of a unique set of genes reveals complex etiology of Schizophrenia

Ashutosh Kumar, Himanshu Narayan Singh, Vikas Pareek, Khursheed Raza, Pavan Kumar, Muneeb A. Faiq, Sankat Mochan, Subrahamanyam Dantham, Ashish Datt Upadhyaya
doi: https://doi.org/10.1101/131623
Ashutosh Kumar
1Department of Anatomy, All India Institute of Medical Sciences (AIIMS). New Delhi-110029, India.
9Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Karaikal (Puducherry)-609602, India
10Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India
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  • For correspondence: aiims.ashu@gmail.com
Himanshu Narayan Singh
2Department of Biochemistry, All India Institute of Medical Sciences (AIIMS). New Delhi-110029, India.
7Functional Genomics Unit, Institute of Genomics and Integrated Biology (IGIB), New Delhi-110025, India.
10Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India
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Vikas Pareek
4Computational Neuroscience and Neuroimaging Division, National Brain Research Centre (NBRC), Manesar, Haryana-122001, India.
10Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India
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Khursheed Raza
1Department of Anatomy, All India Institute of Medical Sciences (AIIMS). New Delhi-110029, India.
10Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India
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Pavan Kumar
1Department of Anatomy, All India Institute of Medical Sciences (AIIMS). New Delhi-110029, India.
10Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India
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Muneeb A. Faiq
5Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences (AIIMS), New Delhi-110029, India.
6Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of medical Sciences (AIIMS), New Delhi-110029, India.
10Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India
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Sankat Mochan
1Department of Anatomy, All India Institute of Medical Sciences (AIIMS). New Delhi-110029, India.
10Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India
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Subrahamanyam Dantham
2Department of Biochemistry, All India Institute of Medical Sciences (AIIMS). New Delhi-110029, India.
8National Institute of Malaria Research (NIMR), Indian Council of Medical Research (ICMR), New Delhi-110077, India
10Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India
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Ashish Datt Upadhyaya
3Department of Biostatistics, All India Institute of Medical Sciences (AIIMS). New Delhi-110029, India.
10Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India
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Abstract

Purpose The etiology of schizophrenia is extensively debated, and multiple factors have been contended to be involved. A panoramic view of the contributing factors in a genome-wide study can be an effective strategy to provide a comprehensive understanding of its causality.

Materials and Methods GSE53987 dataset downloaded from GEO-database, which comprised mRNA expression data of post-mortem brain tissue across three regions from control and age-matched subjects of schizophrenia (N= Hippocampus (HIP): C-15, T-18, Prefrontal cortex (PFC): C-15, T-19, Associative striatum (STR): C-18, T-18). Bio-conductor-affy-package used to compute mRNA expression, and further t-test applied to investigate differential gene expression. The analysis of the derived genes performed using PANTHER Classification System and NCBI database.

Results A set of 40 genes showed significantly altered (p<0.01) expression across all three brain regions. The analyses unraveled genes implicated in biological processes and events, and molecular pathways relating basic neuronal functions.

Conclusions The deviant expression of genes maintaining basic cell machinery explains compromised neuronal processing in SCZ.

Abbreviations Schizophrenia (SCZ), Hippocampus (HIP), Associative striatum (STR), Prefrontal cortex (PFC)

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted July 28, 2017.
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Altered expression of a unique set of genes reveals complex etiology of Schizophrenia
Ashutosh Kumar, Himanshu Narayan Singh, Vikas Pareek, Khursheed Raza, Pavan Kumar, Muneeb A. Faiq, Sankat Mochan, Subrahamanyam Dantham, Ashish Datt Upadhyaya
bioRxiv 131623; doi: https://doi.org/10.1101/131623
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Altered expression of a unique set of genes reveals complex etiology of Schizophrenia
Ashutosh Kumar, Himanshu Narayan Singh, Vikas Pareek, Khursheed Raza, Pavan Kumar, Muneeb A. Faiq, Sankat Mochan, Subrahamanyam Dantham, Ashish Datt Upadhyaya
bioRxiv 131623; doi: https://doi.org/10.1101/131623

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