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Organization of the Drosophila larval visual circuit

Ivan Larderet, Pauline M. J. Fritsch, Nanaë Gendre, Larisa Neagu-Maier, Rick D. Fetter, Casey Schneider-Mizell, James W. Truman, Marta Zlatic, Albert Cardona, Simon G. Sprecher
doi: https://doi.org/10.1101/133686
Ivan Larderet
aDepartment of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland
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Pauline M. J. Fritsch
aDepartment of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland
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Nanaë Gendre
aDepartment of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland
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Larisa Neagu-Maier
aDepartment of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland
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Rick D. Fetter
bHoward Hughes Medical Institute at Janelia Research Campus, Ashburn, Virginia, USA
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Casey Schneider-Mizell
bHoward Hughes Medical Institute at Janelia Research Campus, Ashburn, Virginia, USA
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James W. Truman
bHoward Hughes Medical Institute at Janelia Research Campus, Ashburn, Virginia, USA
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Marta Zlatic
bHoward Hughes Medical Institute at Janelia Research Campus, Ashburn, Virginia, USA
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Albert Cardona
bHoward Hughes Medical Institute at Janelia Research Campus, Ashburn, Virginia, USA
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Simon G. Sprecher
aDepartment of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland
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  • For correspondence: simon.sprecher@unifr.ch
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Abstract

Visual systems transduce, process and transmit light-dependent environmental cues. Computation of visual features depends on the types of photoreceptor neurons (PR) present, the organization of the eye and the wiring of the underlying neural circuit. Here, we describe the circuit architecture of the visual system of Drosophila larvae by mapping the synaptic wiring diagram and neurotransmitters. By contacting different targets, the two larval PR-subtypes create parallel circuits potentially underlying the computation of absolute light intensity and temporal light changes already within this first visual processing center. Locally processed visual information then signals via dedicated projection interneurons to higher brain areas including the lateral horn and mushroom body. The stratified structure of the LON suggests common organizational principles with the adult fly and vertebrate visual systems. The complete synaptic wiring diagram of the LON paves the way to understanding how circuits with reduced numerical complexity control wide ranges of behaviors.

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Posted May 05, 2017.
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Organization of the Drosophila larval visual circuit
Ivan Larderet, Pauline M. J. Fritsch, Nanaë Gendre, Larisa Neagu-Maier, Rick D. Fetter, Casey Schneider-Mizell, James W. Truman, Marta Zlatic, Albert Cardona, Simon G. Sprecher
bioRxiv 133686; doi: https://doi.org/10.1101/133686
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Organization of the Drosophila larval visual circuit
Ivan Larderet, Pauline M. J. Fritsch, Nanaë Gendre, Larisa Neagu-Maier, Rick D. Fetter, Casey Schneider-Mizell, James W. Truman, Marta Zlatic, Albert Cardona, Simon G. Sprecher
bioRxiv 133686; doi: https://doi.org/10.1101/133686

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