Article Information
History
- May 4, 2017.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Phoebe S. Tsoi1,
- Kyoungjae J. Choi1,
- Paul G. Leonard2,
- Antons Sizovs1,
- Mahdi Muhammad Moosa1,
- Kevin R. MacKenzie1,3,
- Josephine C. Ferreon1,* and
- Allan Chris M. Ferreon1,*
- 1Department of Pharmacology and Chemical Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
- 2Department of Genomic Medicine and Core for Biomolecular Structure and Function, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
- 3Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
- ↵*Corresponding authors: E-mail: allan.ferreon{at}bcm.edu; josephine.ferreon{at}bcm.edu
Contributions: J.C.F. and A.C.F. designed the experiments; P.S.T. and A.C.F. performed and analyzed the ensemble CD and fluorescence spectroscopy, and single-molecule FRET experiments. P.S.T. and J.C.F. performed and analyzed the NMR experiments. K.J.C. prepared the TDP-43 DNA constructs and performed the imaging experiments. K.J.C., J.C.F. and A.C.F. purified and prepared the TDP-43 protein samples. P.G.L. carried out the analytical SEC and sedimentation velocity experiments. A.S. and J.C.F. performed the SEC-static light scattering experiments. K.R.M., M.M.M., J.C.F. and A.C.F wrote the manuscript, with inputs from all other authors.