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Imp/Syp temporal gradients govern decommissioning of Drosophila neural stem cells

Ching-Po Yang, Tamsin J. Samuels, Yaling Huang, Lu Yang, David Ish-Horowicz, Ilan Davis, View ORCID ProfileTzumin Lee
doi: https://doi.org/10.1101/136655
Ching-Po Yang
1Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA, USA.
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Tamsin J. Samuels
2Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
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Yaling Huang
1Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA, USA.
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Lu Yang
2Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
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David Ish-Horowicz
2Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
3MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom.
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Ilan Davis
2Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
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Tzumin Lee
1Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA, USA.
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  • ORCID record for Tzumin Lee
  • For correspondence: leet@janelia.hhmi.org
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Abstract

Timing of Drosophila neuroblast decommissioning is controlled in a lineage-specific manner. Following a prepupal ecdysone pulse, the ecdysone receptor and mediator complex cause neuroblasts to shrink. Shrinking is followed by nuclear accumulation of Prospero and cell cycle exit. Only mushroom body (MB) neuroblasts escape early pupal termination. Here, we demonstrate that the opposing temporal gradients of Imp and Syp RNA-binding proteins that govern temporal fate also regulate neuroblast decommissioning. The Imp gradient declines slower in MB neuroblasts so they still express Imp when it is absent from others. The presence of Imp in MB neuroblasts prevents decommissioning partly through inhibiting the mediator complex. Moreover, a timely induction of Imp can protect many non-MB neuroblasts from aging. We also show that the increasing Syp gradient permits Prospero accumulation and neuroblast termination. Together our results reveal that progeny temporal fate and progenitor decommissioning are co-regulated in protracted neuronal lineages.

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Posted May 10, 2017.
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Imp/Syp temporal gradients govern decommissioning of Drosophila neural stem cells
Ching-Po Yang, Tamsin J. Samuels, Yaling Huang, Lu Yang, David Ish-Horowicz, Ilan Davis, Tzumin Lee
bioRxiv 136655; doi: https://doi.org/10.1101/136655
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Imp/Syp temporal gradients govern decommissioning of Drosophila neural stem cells
Ching-Po Yang, Tamsin J. Samuels, Yaling Huang, Lu Yang, David Ish-Horowicz, Ilan Davis, Tzumin Lee
bioRxiv 136655; doi: https://doi.org/10.1101/136655

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