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Response-time behaviors of intercellular communication network motifs

Kevin Thurley, Lani F Wu, Steven J Altschuler
doi: https://doi.org/10.1101/136952
Kevin Thurley
1Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA
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Lani F Wu
1Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA
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Steven J Altschuler
1Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA
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Abstract

Cell-to-cell communication networks have critical roles in diverse organismal processes, such as coordinating tissue development or immune cell response. However, compared to intracellular signal transduction networks, the function and engineering principles of cell-to-cell communication networks are far less understood. Here, we study cell-to-cell communication networks using a framework that models the input-to-output relationship of intracellular signal transduction networks with a single function—the response-time distribution. We identify a prototypic response-time distribution—the gamma distribution—arising in both experimental data sets and mathematical models of signal-transduction pathways. We find that simple cell-to-cell communication circuits can generate bimodal response-time distributions, and can control synchronization and delay of cell-population responses independently. We apply our modeling approach to explain otherwise puzzling data on cytokine secretion onset times in T cells. Our approach can be used to predict communication network structure using experimentally accessible input-to-output measurements and without detailed knowledge of intermediate steps.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 23, 2017.
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Response-time behaviors of intercellular communication network motifs
Kevin Thurley, Lani F Wu, Steven J Altschuler
bioRxiv 136952; doi: https://doi.org/10.1101/136952
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Response-time behaviors of intercellular communication network motifs
Kevin Thurley, Lani F Wu, Steven J Altschuler
bioRxiv 136952; doi: https://doi.org/10.1101/136952

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