Abstract
Ionic currents, whether measured as conductance amplitude or as ion channel transcript levels, can vary many-fold within a population of identified neurons. This variability has been observed in multiple invertebrate neuronal types, but they do so in a coordinated manner such that their magnitudes are correlated. These conductance correlations are thought to reflect a tight homeostasis of cellular excitability that enhances the robustness and stability of neuronal activity over long stretches of time. Notably, although such ionic current correlations are well documented in invertebrates, they have not been reported in vertebrates. Here we demonstrate with two examples, identified mouse hippocampal granule cells and cholinergic basal forebrain neurons, that ionic current correlations is a ubiquitous phenomenon expressed by a number of species across phyla.
Footnotes
Alfredo Kirkwood Johns Hopkins Zanvyl Krieger Mind/Brain Institute, Rm 350 Dunning Hall, and The Solomon H. Snyder Department of Neuroscience Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 Phone: 410-516-8640 / Fax: 410-516-8648 Email: kirkwood{at}jhu.edu
