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Ionic current correlations are ubiquitous across phyla

Trinh Tran, Cagri T. Unal, View ORCID ProfileLaszlo Zaborszky, View ORCID ProfileHoracio Rotstein, View ORCID ProfileAlfredo Kirkwood, View ORCID ProfileJorge Golowasch
doi: https://doi.org/10.1101/137133
Trinh Tran
2Johns Hopkins Zanvyl Krieger Mind/Brain Institute, Rm 350 Dunning Hall, and The Solomon H. Snyder Department of Neuroscience Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
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Cagri T. Unal
1Center for Molecular and Behavioral Neuroscience, Behavioral and Neural Science Graduate Program, Rutgers University-Newark Newark, NJ 07102
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Laszlo Zaborszky
1Center for Molecular and Behavioral Neuroscience, Behavioral and Neural Science Graduate Program, Rutgers University-Newark Newark, NJ 07102
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Horacio Rotstein
3Department of Mathematical Sciences New Jersey Institute of Technology University Heights, Newark, NJ 07102
5Institute for Brain and Neuroscience Research New Jersey Institute of Technology University Heights, Newark, NJ 07102
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Alfredo Kirkwood
2Johns Hopkins Zanvyl Krieger Mind/Brain Institute, Rm 350 Dunning Hall, and The Solomon H. Snyder Department of Neuroscience Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
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Jorge Golowasch
4Federated Department of Biological Sciences New Jersey Institute of Technology University Heights, Newark, NJ 07102
5Institute for Brain and Neuroscience Research New Jersey Institute of Technology University Heights, Newark, NJ 07102
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Abstract

Ionic currents, whether measured as conductance amplitude or as ion channel transcript levels, can vary many-fold within a population of identified neurons. This variability has been observed in multiple invertebrate neuronal types, but they do so in a coordinated manner such that their magnitudes are correlated. These conductance correlations are thought to reflect a tight homeostasis of cellular excitability that enhances the robustness and stability of neuronal activity over long stretches of time. Notably, although such ionic current correlations are well documented in invertebrates, they have not been reported in vertebrates. Here we demonstrate with two examples, identified mouse hippocampal granule cells and cholinergic basal forebrain neurons, that ionic current correlations is a ubiquitous phenomenon expressed by a number of species across phyla.

Footnotes

  • Alfredo Kirkwood Johns Hopkins Zanvyl Krieger Mind/Brain Institute, Rm 350 Dunning Hall, and The Solomon H. Snyder Department of Neuroscience Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 Phone: 410-516-8640 / Fax: 410-516-8648 Email: kirkwood{at}jhu.edu

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 12, 2017.
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Ionic current correlations are ubiquitous across phyla
Trinh Tran, Cagri T. Unal, Laszlo Zaborszky, Horacio Rotstein, Alfredo Kirkwood, Jorge Golowasch
bioRxiv 137133; doi: https://doi.org/10.1101/137133
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Ionic current correlations are ubiquitous across phyla
Trinh Tran, Cagri T. Unal, Laszlo Zaborszky, Horacio Rotstein, Alfredo Kirkwood, Jorge Golowasch
bioRxiv 137133; doi: https://doi.org/10.1101/137133

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