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Deciphering the developmental program in the ascidian Ciona intestinalis just prior to gastrulation

Yoshito Harada
doi: https://doi.org/10.1101/137166
Yoshito Harada
Sugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University, Sugashima, Toba 517-0004, Japan
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ABSTRACT

The embryo of the ascidian Ciona intestinalis displays striking anatomical simplicity, with an invariant cleavage pattern during development. It has a monoploid genome like the model organisms Drosophila melanogaster and Caenorhabditis elegans, whereas vertebrates generally exhibit tetraploidy. In this study, I took advantage of these characteristics to investigate the development of the organism as one reverse-engineers an industrial product. First, the spatial expression of 211 genes was digitalized. Some genes showed variable expression patterns, which might reflect multiple snapshots of a single temporally dynamic expression at different times. Several developmental territories of the embryo were considered to be very similar to each other; however, this digitalization of gene expression patterns showed that differences occurred between individual blastomeres even within a single developmental territory. Furthermore, Ciona Brachyury (Ci-Bra) was expressed in those blastomeres in which both Fox (forkhead-box) A-a and Zic (zinc-finger) L were expressed, these proteins being upstream regulators of Ci-Bra. The approach described enables the developmental program to be studied in silico.

SUMMARY STATEMENT A detailed expansion of our knowledge on an animal developmental program by using already published gene expression data with the aid of computers

Footnotes

  • E-mail: yharada{at}bio.nagoya-u.ac.jp Phone: +81-52-789-5514 Fax: +81-52-789-4204

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 12, 2017.
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Deciphering the developmental program in the ascidian Ciona intestinalis just prior to gastrulation
Yoshito Harada
bioRxiv 137166; doi: https://doi.org/10.1101/137166
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Deciphering the developmental program in the ascidian Ciona intestinalis just prior to gastrulation
Yoshito Harada
bioRxiv 137166; doi: https://doi.org/10.1101/137166

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