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The core transcriptome of mammalian placentas and the divergence of expression with placental shape

View ORCID ProfileDon L. Armstrong, Michael R. McGowen, Amy Weckle, Priyadarshini Pantham, Jason Caravas, Dalen Agnew, Kurt Benirschke, Sue Savage-Rumbaugh, Eviatar Nevo, Chong J. Kim, Günter P. Wagner, Roberto Romero, Derek E. Wildman
doi: https://doi.org/10.1101/137554
Don L. Armstrong
aCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • ORCID record for Don L. Armstrong
Michael R. McGowen
bSchool of Biological and Chemical Sciences, Queen Mary, University of London, London, UK
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Amy Weckle
aCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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Priyadarshini Pantham
aCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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Jason Caravas
cCenter for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA
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Dalen Agnew
dDiagnostic Center for Population and Animal Health, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA
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Kurt Benirschke
eDepartment of Pathology, University of California San Diego, La Jolla, CA, USA
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Sue Savage-Rumbaugh
fGreat Ape Trust/Bonobo Hope Sanctuary, Des Moines, IA, USA
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Eviatar Nevo
lThe Institute of Evolution, University of Haifa, Haifa, Israel
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Chong J. Kim
gPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Detroit, MI, USA
hDepartment of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
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Günter P. Wagner
jDepartment of Ecology and Evolutionary Biology and Yale Systems Biology Institute, Yale University, New Haven, CT, USA
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Roberto Romero
gPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Detroit, MI, USA
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Derek E. Wildman
aCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA
fGreat Ape Trust/Bonobo Hope Sanctuary, Des Moines, IA, USA
kDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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Abstract

Introduction The placenta is arguably the most anatomically variable organ in mammals even though its primary function is conserved.

Method Using RNA-Seq, we measured the expression profiles of 55 term placentas of 14 species of mammals representing all major eutherian superordinal clades and marsupials, and compared the evolution of expression across clades.

Results We identified a set of 115 core genes which is expressed (FPKM ≥ 10) in all eutherian placentas, including genes with immune-modulating properties (ANXA2, ANXA1, S100A11, S100A10, and LGALS1), cell-cell interactions (LAMC1, LUM, and LGALS1), invasion (GRB2 and RALB) and syncytialization (ANXA5 and ANXA1). We also identified multiple pre-eclampsia associated genes which are differentially expressed in Homo sapiens when compared to the other 13 species. Multiple genes are significantly associated with placenta morphology, including EREG and WNT5A which are both associated with placental shape.

Discussion 115 genes are important for the core functions of the placenta in all eutherian species analyzed. The molecular functions and pathways enriched in the core placenta align with the evolutionarily conserved functionality of the placenta.

Footnotes

  • Email addresses: don{at}donarmstrong.com (Don L. Armstrong), 1mmcgowen1{at}gmail.com (Michael R. McGowen), aweckle{at}illinois.edu (Amy Weckle), pantham{at}illinois.edu (Priyadarshini Pantham), jacaravas{at}gmail.com (Jason Caravas), agnewd{at}dcpah.msu.edu (Dalen Agnew), kbenirschke{at}ucsd.edu (Kurt Benirschke), suerumbaugh{at}gmail.com (Sue Savage-Rumbaugh), nevo{at}research.haifa.ac.il (Eviatar Nevo), ckim{at}amc.seoul.kr (Chong J. Kim), gunter.wagner{at}yale.edu (Günter P. Wagner), prbchiefstaff{at}med.wayne.edu (Roberto Romero), wildmand{at}illinois.edu (Derek E. Wildman)

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 12, 2017.
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The core transcriptome of mammalian placentas and the divergence of expression with placental shape
Don L. Armstrong, Michael R. McGowen, Amy Weckle, Priyadarshini Pantham, Jason Caravas, Dalen Agnew, Kurt Benirschke, Sue Savage-Rumbaugh, Eviatar Nevo, Chong J. Kim, Günter P. Wagner, Roberto Romero, Derek E. Wildman
bioRxiv 137554; doi: https://doi.org/10.1101/137554
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The core transcriptome of mammalian placentas and the divergence of expression with placental shape
Don L. Armstrong, Michael R. McGowen, Amy Weckle, Priyadarshini Pantham, Jason Caravas, Dalen Agnew, Kurt Benirschke, Sue Savage-Rumbaugh, Eviatar Nevo, Chong J. Kim, Günter P. Wagner, Roberto Romero, Derek E. Wildman
bioRxiv 137554; doi: https://doi.org/10.1101/137554

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