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Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity

View ORCID ProfileNathan S. Jacobs, Ron D. Frostig
doi: https://doi.org/10.1101/137562
Nathan S. Jacobs
1Department of Neurobiology and Behavior, University of California, Irvine, California 92697-4550, USA
3The Center for Learning and Memory, University of California, Irvine, California 92697-4550, USA
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  • ORCID record for Nathan S. Jacobs
Ron D. Frostig
1Department of Neurobiology and Behavior, University of California, Irvine, California 92697-4550, USA
2Department of Biomedical Engineering, University of California, Irvine, California 92697-4550, USA
3The Center for Learning and Memory, University of California, Irvine, California 92697-4550, USA
4The Center for Hearing Research, University of California, Irvine, California 92697-4550, USA
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Abstract

The posterior medial barrel subfield (PMBSF) of rat primary somatosensory cortex exquisitely demonstrates topography and columnar organization, defining features of sensory cortices in the mammalian brain. Optical imaging and neuronal recordings in rat PMBSF demonstrates how evoked cortical activity following single whisker stimulation also rapidly spreads laterally into surrounding cortices, disregarding columnar and modality boundaries. The current study quantifies the spatial prominence of such lateral activity spreads by demonstrating that functional connectivity between laterally spaced cortical locations is actually stronger than between vertically spaced cortical locations. Further, the total amount of evoked activity within and beyond single column boundaries was quantified based on intrinsic signal optical imaging, single units and local field potentials (LFPs) recordings, revealing that the vast majority of whisker evoked activity in PMBSF occurs beyond columnar boundaries. Finally, a simple two layer artificial neural network model of PMBSF demonstrates the capacity of extra-columnar evoked activity spread to provide a foundation for accurate whisker stimulus classification that is robust to random scaling of inputs and local noise. Indeed, classification performance improved when more of the lateral spread was included in the model, providing further evidence for the relevance of the lateral spread.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 12, 2017.
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Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity
Nathan S. Jacobs, Ron D. Frostig
bioRxiv 137562; doi: https://doi.org/10.1101/137562
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Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity
Nathan S. Jacobs, Ron D. Frostig
bioRxiv 137562; doi: https://doi.org/10.1101/137562

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