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A model for adult organ resizing demonstrates stem cell scaling through a tunable commitment rate

XinXin Du, Lucy Erin O’Brien, Ingmar Riedel-Kruse
doi: https://doi.org/10.1101/137638
XinXin Du
1Department of Molecular and Cellular Physiology, Stanford University, 279 Campus Drive, Stanford, CA 94305
2Department of Bioengineering, Stanford University, 318 Campus Drive, Stanford, CA 94305
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Lucy Erin O’Brien
1Department of Molecular and Cellular Physiology, Stanford University, 279 Campus Drive, Stanford, CA 94305
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Ingmar Riedel-Kruse
2Department of Bioengineering, Stanford University, 318 Campus Drive, Stanford, CA 94305
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Abstract

Many adult organs grow or shrink to accommodate different physiological demands. Often, as total cell number changes, stem cell number changes proportionally in a phenomenon called ‘stem cell scaling’. The cellular behaviors that give rise to scaling are unknown. Here we study two complementary theoretical models of the adult Drosophila midgut, a stem cell-based organ with known resizing dynamics. First, we derive a differential equations model of midgut resizing and show that the in vivo kinetics of growth can be recapitulated if the rate of fate commitment depends on the tissue’s stem cell proportion. Second, we develop a twodimensional simulation of the midgut and find that proportion-dependent commitment rate and stem cell scaling can arise phenomenologically from the stem cells’ exploration of physical tissue space during its lifetime. Together, these models provide a biophysical understanding of how stem cell scaling is maintained during organ growth and shrinkage.

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Posted May 13, 2017.
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A model for adult organ resizing demonstrates stem cell scaling through a tunable commitment rate
XinXin Du, Lucy Erin O’Brien, Ingmar Riedel-Kruse
bioRxiv 137638; doi: https://doi.org/10.1101/137638
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A model for adult organ resizing demonstrates stem cell scaling through a tunable commitment rate
XinXin Du, Lucy Erin O’Brien, Ingmar Riedel-Kruse
bioRxiv 137638; doi: https://doi.org/10.1101/137638

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