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Cellular adaptation through fitness-directed transcriptional tuning

View ORCID ProfilePeter L. Freddolino, Jamie Yang, View ORCID ProfileSaeed Tavazoie
doi: https://doi.org/10.1101/137810
Peter L. Freddolino
1Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York City, NY, 10032, USA
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Jamie Yang
1Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York City, NY, 10032, USA
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Saeed Tavazoie
1Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York City, NY, 10032, USA
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  • For correspondence: st2744@columbia.edu
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Summary

Cells adapt to changes in their environment through transcriptional responses that are hard-coded in their regulatory networks. Such dedicated pathways, however, may be inadequate for adaptation to novel or extreme environments. We propose the existence of a fitness optimization mechanism that tunes the global transcriptional output of a genome to match arbitrary external conditions in the absence of dedicated gene-regulatory networks. We provide evidence for the proposed tuning mechanism in the adaptation of Saccharomyces cerevisiae to laboratory-engineered environments that are foreign to its native gene-regulatory network. We show that transcriptional tuning operates locally at individual gene promoters and its efficacy is modulated by genetic perturbations to chromatin modification machinery.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 14, 2017.
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Cellular adaptation through fitness-directed transcriptional tuning
Peter L. Freddolino, Jamie Yang, Saeed Tavazoie
bioRxiv 137810; doi: https://doi.org/10.1101/137810
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Cellular adaptation through fitness-directed transcriptional tuning
Peter L. Freddolino, Jamie Yang, Saeed Tavazoie
bioRxiv 137810; doi: https://doi.org/10.1101/137810

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