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Integrating planar polarity and tissue mechanics in computational models of epithelial morphogenesis

View ORCID ProfileKatherine H. Fisher, View ORCID ProfileDavid Strutt, View ORCID ProfileAlexander G. Fletcher
doi: https://doi.org/10.1101/138172
Katherine H. Fisher
1Bateson Centre, University of Sheffield, Firth Court, Western Bank, Sheffield, S102TN
2Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN
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  • ORCID record for Katherine H. Fisher
David Strutt
1Bateson Centre, University of Sheffield, Firth Court, Western Bank, Sheffield, S102TN
2Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN
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Alexander G. Fletcher
1Bateson Centre, University of Sheffield, Firth Court, Western Bank, Sheffield, S102TN
3School of Mathematics and Statistics, University of Sheffield, Hicks Building, Hounsfield Road, Sheffield, S3 7RH
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  • For correspondence: a.g.fletcher@sheffield.ac.uk
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Abstract

Cells in many epithelial tissues are polarised orthogonally to their apicobasal axis. Such planar polarity ensures that tissue shape and structure are properly organised. Disruption of planar polarity can result in developmental defects such as failed neural tube closure and cleft palette. Recent advances in molecular and live-imaging techniques have implicated both secreted morphogens and mechanical forces as orienting cues for planar polarisation. Components of planar polarity pathways act upstream of cytoskeletal effectors, which can alter cell mechanics in a polarised manner. The study of cell polarisation thus provides a system for dissecting the interplay between chemical and mechanical signals in development. Here, we discuss how different computational models have contributed to our understanding of the mechanisms underlying planar polarity in animal tissues, focusing on recent efforts to integrate cell signalling and tissue mechanics. We conclude by discussing ways in which computational models could be improved to further our understanding of how planar polarity and tissue mechanics are coordinated during development.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted May 15, 2017.
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Integrating planar polarity and tissue mechanics in computational models of epithelial morphogenesis
Katherine H. Fisher, David Strutt, Alexander G. Fletcher
bioRxiv 138172; doi: https://doi.org/10.1101/138172
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Integrating planar polarity and tissue mechanics in computational models of epithelial morphogenesis
Katherine H. Fisher, David Strutt, Alexander G. Fletcher
bioRxiv 138172; doi: https://doi.org/10.1101/138172

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