Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Mitochondrial genetic effects on reproductive success: signatures of positive intra-sexual, but negative inter-sexual pleiotropy

M. Florencia Camus, Damian K. Dowling
doi: https://doi.org/10.1101/138180
M. Florencia Camus
1School of Biological Sciences, Monash University, 3800, Australia
2Research Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Damian K. Dowling
1School of Biological Sciences, Monash University, 3800, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Mitochondria contain their own DNA, and numerous studies have reported that genetic variation in this (mt)DNA sequence modifies the expression of life-history phenotypes. Maternal inheritance of mitochondria adds a layer of complexity to trajectories of mtDNA evolution, because theory predicts the accumulation of mtDNA mutations that are male-biased in effect. While it is clear that mitochondrial genomes routinely harbor genetic variation that affects components of reproductive performance, the extent to which this variation is sex-biased, or even sex-specific in effect, remains elusive. This is because nearly all previous studies have failed to examine mitochondrial genetic effects on both male and female reproductive performance within the one-and-the-same study. Here, we show that variation across naturally-occurring mitochondrial haplotypes affects components of reproductive success in both sexes, in Drosophila melanogaster. However, while we uncovered evidence for positive pleiotropy, across haplotypes, in effects on separate components of reproductive success when measured within the same sex, such patterns were not evident across sexes. Rather, we found a pattern of sexual antagonism across haplotypes on some reproductive parameters. This suggests the pool of polymorphisms that delineate global mtDNA haplotypes is likely to have been partly shaped by maternal transmission of mtDNA and its evolutionary consequences.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted May 15, 2017.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Mitochondrial genetic effects on reproductive success: signatures of positive intra-sexual, but negative inter-sexual pleiotropy
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Mitochondrial genetic effects on reproductive success: signatures of positive intra-sexual, but negative inter-sexual pleiotropy
M. Florencia Camus, Damian K. Dowling
bioRxiv 138180; doi: https://doi.org/10.1101/138180
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Mitochondrial genetic effects on reproductive success: signatures of positive intra-sexual, but negative inter-sexual pleiotropy
M. Florencia Camus, Damian K. Dowling
bioRxiv 138180; doi: https://doi.org/10.1101/138180

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Evolutionary Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4691)
  • Biochemistry (10381)
  • Bioengineering (7698)
  • Bioinformatics (26381)
  • Biophysics (13553)
  • Cancer Biology (10735)
  • Cell Biology (15465)
  • Clinical Trials (138)
  • Developmental Biology (8509)
  • Ecology (12844)
  • Epidemiology (2067)
  • Evolutionary Biology (16890)
  • Genetics (11417)
  • Genomics (15499)
  • Immunology (10643)
  • Microbiology (25261)
  • Molecular Biology (10241)
  • Neuroscience (54610)
  • Paleontology (402)
  • Pathology (1671)
  • Pharmacology and Toxicology (2900)
  • Physiology (4356)
  • Plant Biology (9265)
  • Scientific Communication and Education (1588)
  • Synthetic Biology (2562)
  • Systems Biology (6789)
  • Zoology (1472)