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Simultaneous activation of parallel sensory pathways promotes a grooming sequence in Drosophila

Stefanie Hampel, Claire E. McKellar, Julie H. Simpson, View ORCID ProfileAndrew M. Seeds
doi: https://doi.org/10.1101/139956
Stefanie Hampel
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147
2Current Address: Institute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, 00901
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Claire E. McKellar
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147
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Julie H. Simpson
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147
3Current address: Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
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Andrew M. Seeds
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147
2Current Address: Institute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, 00901
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  • ORCID record for Andrew M. Seeds
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Abstract

A central model that describes how behavioral sequences are produced features a neural architecture that readies different movements simultaneously, and a mechanism where prioritized suppression between the movements determines their sequential performance. We previously described a model whereby suppression drives a Drosophila grooming sequence that is induced by simultaneous activation of different sensory pathways that each elicit a distinct movement (Seeds et al. 2014). Here, we confirm this model using transgenic expression to identify and optogenetically activate sensory neurons that elicit specific grooming movements. Simultaneous activation of different sensory pathways elicits a grooming sequence that resembles the naturally induced sequence. Moreover, the sequence proceeds after the sensory excitation is terminated, indicating that a persistent trace of this excitation induces the next grooming movement once the previous one is performed. This reveals a mechanism whereby parallel sensory inputs can be integrated and stored to elicit a delayed and sequential grooming response.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 19, 2017.
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Simultaneous activation of parallel sensory pathways promotes a grooming sequence in Drosophila
Stefanie Hampel, Claire E. McKellar, Julie H. Simpson, Andrew M. Seeds
bioRxiv 139956; doi: https://doi.org/10.1101/139956
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Simultaneous activation of parallel sensory pathways promotes a grooming sequence in Drosophila
Stefanie Hampel, Claire E. McKellar, Julie H. Simpson, Andrew M. Seeds
bioRxiv 139956; doi: https://doi.org/10.1101/139956

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