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Germline de novo mutation clusters arise during oocyte aging in genomic regions with increased double-strand break incidence
View ORCID ProfileJakob M. Goldmann, Vladimir B. Seplyarskiy, Wendy S.W. Wong, Thierry Vilboux, Dale L. Bodian, Benjamin D. Solomon, Joris A. Veltman, John F. Deeken, Christian Gilissen, John E. Niederhuber
doi: https://doi.org/10.1101/140111
Jakob M. Goldmann
1Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 10, 6525 GA Nijmegen, the Netherlands
Vladimir B. Seplyarskiy
2Division of Genetics, Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.
3Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute), Bolshoi Karetny pereulok 19, Moscow 127994, Russia
Wendy S.W. Wong
4Inova Translational Medicine Institute (ITMI), Inova Health Systems, Falls Church, VA, USA
Thierry Vilboux
4Inova Translational Medicine Institute (ITMI), Inova Health Systems, Falls Church, VA, USA
Dale L. Bodian
4Inova Translational Medicine Institute (ITMI), Inova Health Systems, Falls Church, VA, USA
Benjamin D. Solomon
4Inova Translational Medicine Institute (ITMI), Inova Health Systems, Falls Church, VA, USA
5Department of Pediatrics, Inova Children’s Hospital, Inova Health System, Falls Church, VA, USA
6Department of Pediatrics, Virginia Commonwealth University School of Medicine, 1201 E Marshall St, Richmond, VA, UAS
Joris A. Veltman
7Department of Human Genetics, Donders Centre for Neuroscience, Radboud University Medical Center, Geert Grooteplein 10, 6525 GA Nijmegen, the Netherlands
8Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle upon Tyne, United Kingdom
John F. Deeken
4Inova Translational Medicine Institute (ITMI), Inova Health Systems, Falls Church, VA, USA
Christian Gilissen
7Department of Human Genetics, Donders Centre for Neuroscience, Radboud University Medical Center, Geert Grooteplein 10, 6525 GA Nijmegen, the Netherlands
John E. Niederhuber
4Inova Translational Medicine Institute (ITMI), Inova Health Systems, Falls Church, VA, USA
9Johns Hopkins University School of Medicine, 733 North Broadway Street, Baltimore, MD, USA
Posted June 30, 2017.
Germline de novo mutation clusters arise during oocyte aging in genomic regions with increased double-strand break incidence
Jakob M. Goldmann, Vladimir B. Seplyarskiy, Wendy S.W. Wong, Thierry Vilboux, Dale L. Bodian, Benjamin D. Solomon, Joris A. Veltman, John F. Deeken, Christian Gilissen, John E. Niederhuber
bioRxiv 140111; doi: https://doi.org/10.1101/140111
Germline de novo mutation clusters arise during oocyte aging in genomic regions with increased double-strand break incidence
Jakob M. Goldmann, Vladimir B. Seplyarskiy, Wendy S.W. Wong, Thierry Vilboux, Dale L. Bodian, Benjamin D. Solomon, Joris A. Veltman, John F. Deeken, Christian Gilissen, John E. Niederhuber
bioRxiv 140111; doi: https://doi.org/10.1101/140111
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