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Life stage associated remodeling of lipid metabolism regulation in the duplicated Atlantic salmon genome

Gareth Gillard, Thomas N. Harvey, Arne Gjuvsland, Yang Jin, Magny Thomassen, Sigbjørn Lien, Michael Leaver, Jacob S. Torgersen, Torgeir R. Hvidsten, Jon Olav Vik, View ORCID ProfileSimen R. Sandve
doi: https://doi.org/10.1101/140442
Gareth Gillard
1Faculty of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås NO-1432, Norway
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Thomas N. Harvey
2Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås NO-1432, Norway
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Arne Gjuvsland
1Faculty of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås NO-1432, Norway
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Yang Jin
3Department of Biology, Norwegian University of Science and Technology, N7491 Trondheim, Norway.
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Magny Thomassen
4Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås NO-1432, Norway
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Sigbjørn Lien
2Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås NO-1432, Norway
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Michael Leaver
5Institute of Aquaculture, School of Natural Sciences, University of Stirling, Pathfoot Building, Stirling FK9 4LA, Scotland, UK
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Jacob S. Torgersen
6AquaGen AS, Ås NO-1432, Norway
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Torgeir R. Hvidsten
1Faculty of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås NO-1432, Norway
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Jon Olav Vik
2Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås NO-1432, Norway
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Simen R. Sandve
2Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås NO-1432, Norway
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  • ORCID record for Simen R. Sandve
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Abstract

Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. These habitat shifts require great phenotypic plasticity. To address the unresolved question of how the shift in diet between fresh and saltwater affects the regulation of metabolic function, we fed salmon contrasting diets in each of the two life stages. Combining transcriptomics with comparative genomics, we found that lipid metabolism undergoes a concerted shift between fresh- and saltwater stages. Lipogenesis and lipid transport become less active in liver after transition to saltwater, while genes for lipid uptake in gut are more expressed in lipid-rich seawater environments. We assess how the whole-genome duplication that gave rise to the salmonids has impacted the evolution of lipid metabolism, and find signatures of pathway-specific selection pressure on gene duplicates, as well as a limited number of cases of increased gene dosage.

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Posted June 15, 2017.
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Life stage associated remodeling of lipid metabolism regulation in the duplicated Atlantic salmon genome
Gareth Gillard, Thomas N. Harvey, Arne Gjuvsland, Yang Jin, Magny Thomassen, Sigbjørn Lien, Michael Leaver, Jacob S. Torgersen, Torgeir R. Hvidsten, Jon Olav Vik, Simen R. Sandve
bioRxiv 140442; doi: https://doi.org/10.1101/140442
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Life stage associated remodeling of lipid metabolism regulation in the duplicated Atlantic salmon genome
Gareth Gillard, Thomas N. Harvey, Arne Gjuvsland, Yang Jin, Magny Thomassen, Sigbjørn Lien, Michael Leaver, Jacob S. Torgersen, Torgeir R. Hvidsten, Jon Olav Vik, Simen R. Sandve
bioRxiv 140442; doi: https://doi.org/10.1101/140442

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