Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans

View ORCID ProfileRosalind Hussey, Emily Witham, Erik Vanstrum, View ORCID ProfileJaleh Mesgarzadeh, Harkaranveer Ratanpal, Supriya Srinivasan
doi: https://doi.org/10.1101/142422
Rosalind Hussey
aDepartment of Molecular Medicine, Department of Neuroscience and Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Rosalind Hussey
Emily Witham
aDepartment of Molecular Medicine, Department of Neuroscience and Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
bCurrent Address: Janssen Pharmaceutical Companies of Johnson and Johnson, 3210 Merryfield Row, San Diego, CA 92121, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Erik Vanstrum
aDepartment of Molecular Medicine, Department of Neuroscience and Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jaleh Mesgarzadeh
aDepartment of Molecular Medicine, Department of Neuroscience and Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
cDepartment of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jaleh Mesgarzadeh
Harkaranveer Ratanpal
aDepartment of Molecular Medicine, Department of Neuroscience and Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
dCurrent Address: Liberty University College of Osteopathic Medicine, 306 Liberty View Lane, Lynchburg, VA 24502, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Supriya Srinivasan
aDepartment of Molecular Medicine, Department of Neuroscience and Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: supriya@scripps.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

The mechanisms by which the sensory environment instructs metabolic homeostasis remains poorly understood. In this report, we show that oxygen, a potent environmental signal, is an important regulator of whole body lipid metabolism. C. elegans oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism under normoxia in the following way: under high oxygen and food absence, URX sensory neurons are activated, and stimulate fat loss in the intestine, the major metabolic organ for C. elegans. Under lower oxygen conditions or when food is present, the BAG sensory neurons respond by repressing the resting properties of the URX neurons. A genetic screen to identify modulators of this effect led to the identification of a BAG-neuron-specific neuropeptide called FLP-17, whose cognate receptor EGL-6 functions in URX neurons. Thus, BAG sensory neurons counterbalance the metabolic effect of tonically active URX neurons via neuropeptide communication. The combined regulatory actions of these neurons serve to precisely tune the rate and extent of fat loss, to the availability of food and oxygen.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted May 26, 2017.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans
Rosalind Hussey, Emily Witham, Erik Vanstrum, Jaleh Mesgarzadeh, Harkaranveer Ratanpal, Supriya Srinivasan
bioRxiv 142422; doi: https://doi.org/10.1101/142422
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans
Rosalind Hussey, Emily Witham, Erik Vanstrum, Jaleh Mesgarzadeh, Harkaranveer Ratanpal, Supriya Srinivasan
bioRxiv 142422; doi: https://doi.org/10.1101/142422

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4377)
  • Biochemistry (9568)
  • Bioengineering (7080)
  • Bioinformatics (24813)
  • Biophysics (12594)
  • Cancer Biology (9940)
  • Cell Biology (14310)
  • Clinical Trials (138)
  • Developmental Biology (7940)
  • Ecology (12090)
  • Epidemiology (2067)
  • Evolutionary Biology (15971)
  • Genetics (10911)
  • Genomics (14721)
  • Immunology (9856)
  • Microbiology (23611)
  • Molecular Biology (9468)
  • Neuroscience (50791)
  • Paleontology (369)
  • Pathology (1537)
  • Pharmacology and Toxicology (2677)
  • Physiology (4004)
  • Plant Biology (8651)
  • Scientific Communication and Education (1507)
  • Synthetic Biology (2388)
  • Systems Biology (6419)
  • Zoology (1345)