Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger; Simon A. Lowe; Nancy T. Malintan; Henry Houlden; Dimitri M. Kullmann; Maria M. Usowicz; Shyam S. Krishnakumar; James J.L. Hodge; James E. Rothman; James E.C. Jepson

doi:10.1101/142679

New Results

Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Henry Houlden, Dimitri M. Kullmann, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson

doi: https://doi.org/10.1101/142679

Roman Praschberger

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Simon A. Lowe

2School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nancy T. Malintan

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Henry Houlden

3Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Dimitri M. Kullmann

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Maria M. Usowicz

2School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Shyam S. Krishnakumar

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

4Department of Cell Biology, Yale School of Medicine, New Haven, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

James J.L. Hodge

2School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

James E. Rothman

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

4Department of Cell Biology, Yale School of Medicine, New Haven, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

James E.C. Jepson

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

5Lead contact

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: j.jepson@ucl.ac.uk

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Supplemental Figure Legends
Figure S1
Figure S2
Figure S3
Figure S4
Figure S5
Figure S6
Figure S7

View the discussion thread.

PreviousNext

Posted May 26, 2017.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Henry Houlden, Dimitri M. Kullmann, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson

bioRxiv 142679; doi: https://doi.org/10.1101/142679

Share This Article:

Citation Tools

Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Henry Houlden, Dimitri M. Kullmann, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson

bioRxiv 142679; doi: https://doi.org/10.1101/142679

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Neuroscience

Subject Areas

All Articles

Animal Behavior and Cognition (2271)
Biochemistry (4388)
Bioengineering (3031)
Bioinformatics (13666)
Biophysics (6085)
Cancer Biology (4742)
Cell Biology (6775)
Clinical Trials (138)
Developmental Biology (4000)
Ecology (6342)
Epidemiology (2054)
Evolutionary Biology (9321)
Genetics (6974)
Genomics (8946)
Immunology (4024)
Microbiology (11530)
Molecular Biology (4544)
Neuroscience (26137)
Paleontology (184)
Pathology (738)
Pharmacology and Toxicology (1239)
Physiology (1831)
Plant Biology (4082)
Scientific Communication and Education (905)
Synthetic Biology (1213)
Systems Biology (3681)
Zoology (668)