Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger; Simon A. Lowe; Nancy T. Malintan; Henry Houlden; Dimitri M. Kullmann; Maria M. Usowicz; Shyam S. Krishnakumar; James J.L. Hodge; James E. Rothman; James E.C. Jepson

doi:10.1101/142679

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Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Henry Houlden, Dimitri M. Kullmann, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson

doi: https://doi.org/10.1101/142679

Roman Praschberger

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

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Simon A. Lowe

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK

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Nancy T. Malintan

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

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Henry Houlden

Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK

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Dimitri M. Kullmann

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

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Maria M. Usowicz

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK

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Shyam S. Krishnakumar

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UKDepartment of Cell Biology, Yale School of Medicine, New Haven, USA

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James J.L. Hodge

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK

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James E. Rothman

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UKDepartment of Cell Biology, Yale School of Medicine, New Haven, USA

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James E.C. Jepson

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UKLead contact

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For correspondence: j.jepson@ucl.ac.uk

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Posted May 26, 2017.

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Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Henry Houlden, Dimitri M. Kullmann, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson

bioRxiv 142679; doi: https://doi.org/10.1101/142679

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Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Henry Houlden, Dimitri M. Kullmann, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson

bioRxiv 142679; doi: https://doi.org/10.1101/142679

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