Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger; Simon A. Lowe; Nancy T. Malintan; Henry Houlden; Dimitri M. Kullmann; Maria M. Usowicz; Shyam S. Krishnakumar; James J.L. Hodge; James E. Rothman; James E.C. Jepson

doi:10.1101/142679

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Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Henry Houlden, Dimitri M. Kullmann, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson

doi: https://doi.org/10.1101/142679

Roman Praschberger

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

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Simon A. Lowe

2School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK

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Nancy T. Malintan

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

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Henry Houlden

3Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK

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Dimitri M. Kullmann

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

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Maria M. Usowicz

2School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK

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Shyam S. Krishnakumar

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

4Department of Cell Biology, Yale School of Medicine, New Haven, USA

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James J.L. Hodge

2School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK

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James E. Rothman

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

4Department of Cell Biology, Yale School of Medicine, New Haven, USA

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James E.C. Jepson

1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

5Lead contact

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For correspondence: j.jepson@ucl.ac.uk

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Posted May 26, 2017.

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Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Henry Houlden, Dimitri M. Kullmann, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson

bioRxiv 142679; doi: https://doi.org/10.1101/142679

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Mutations in Membrin/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity

Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Henry Houlden, Dimitri M. Kullmann, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson

bioRxiv 142679; doi: https://doi.org/10.1101/142679

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