Altered neocortical gene expression, brain overgrowth and functional over-connectivity in Chd8 haploinsufficient mice

Philipp Suetterlin; Shaun Hurley; Conor Mohan; Kimberley L. H. Riegman; Marco Pagani; Angela Caruso; Jacob Ellegood; Alberto Galbusera; Ivan Crespo-Enriquez; Caterina Michetti; Yohan Yee; Robert Ellingford; Olivier Brock; Alessio Delogu; Philippa Francis-West; Jason P. Lerch; Maria Luisa Scattoni; Alessandro Gozzi; Cathy Fernandes; M. Albert Basson

doi:10.1101/143552

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Altered neocortical gene expression, brain overgrowth and functional over-connectivity in Chd8 haploinsufficient mice

View ORCID ProfilePhilipp Suetterlin, Shaun Hurley, Conor Mohan, Kimberley L. H. Riegman, Marco Pagani, Angela Caruso, Jacob Ellegood, Alberto Galbusera, Ivan Crespo-Enriquez, Caterina Michetti, Yohan Yee, Robert Ellingford, Olivier Brock, Alessio Delogu, Philippa Francis-West, Jason P. Lerch, Maria Luisa Scattoni, Alessandro Gozzi, Cathy Fernandes, M. Albert Basson

doi: https://doi.org/10.1101/143552

Philipp Suetterlin

1Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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ORCID record for Philipp Suetterlin

Shaun Hurley

1Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Conor Mohan

1Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Kimberley L. H. Riegman

1Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Marco Pagani

2Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, 38068 Rovereto, TN, Italy

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Angela Caruso

3Neurotoxicology and Neuroendocrinology Section, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299,00161 Rome, Italy

4School of Behavioural Neuroscience, Department of Psychology, Sapienza University of Rome, via dei Marsi 78, 00185, Rome, Italy

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Jacob Ellegood

5Department of Medical Biophysics, University of Toronto, Mouse Imaging Centre, Hospital for Sick Children, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada

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Alberto Galbusera

2Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, 38068 Rovereto, TN, Italy

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Ivan Crespo-Enriquez

1Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Caterina Michetti

3Neurotoxicology and Neuroendocrinology Section, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299,00161 Rome, Italy

6Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy

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Yohan Yee

5Department of Medical Biophysics, University of Toronto, Mouse Imaging Centre, Hospital for Sick Children, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada

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Robert Ellingford

1Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Olivier Brock

7Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK

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Alessio Delogu

7Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK

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Philippa Francis-West

1Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Jason P. Lerch

5Department of Medical Biophysics, University of Toronto, Mouse Imaging Centre, Hospital for Sick Children, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada

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Maria Luisa Scattoni

3Neurotoxicology and Neuroendocrinology Section, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299,00161 Rome, Italy

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Alessandro Gozzi

2Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, 38068 Rovereto, TN, Italy

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Cathy Fernandes

8MRC Social, Genetic & Developmental Psychiatry Centre, PO82, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, London SE5 8AF, UK

9MRC Centre for Neurodevelopmental Disorders, King’s College London, 4th floor, New Hunt’s House, London SE1 1UL, UK

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M. Albert Basson

1Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

9MRC Centre for Neurodevelopmental Disorders, King’s College London, 4th floor, New Hunt’s House, London SE1 1UL, UK

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For correspondence: albert.basson@kcl.ac.uk

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Table S1
Table S2-S4
Table S5-S10
Table S11

Extended Data Table 2-1
Extended Data Tables 5-1 to 5-3
Extended Data Tables 5-4 to 5-9

Supplementary Table 1
Supplementary Tables 2-4
Supplementary Tables 5-10

Supplementary Table 1
Supplementary Tables 2-4
Supplementary Tables 5-10

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Posted February 27, 2018.

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Altered neocortical gene expression, brain overgrowth and functional over-connectivity in Chd8 haploinsufficient mice

Philipp Suetterlin, Shaun Hurley, Conor Mohan, Kimberley L. H. Riegman, Marco Pagani, Angela Caruso, Jacob Ellegood, Alberto Galbusera, Ivan Crespo-Enriquez, Caterina Michetti, Yohan Yee, Robert Ellingford, Olivier Brock, Alessio Delogu, Philippa Francis-West, Jason P. Lerch, Maria Luisa Scattoni, Alessandro Gozzi, Cathy Fernandes, M. Albert Basson

bioRxiv 143552; doi: https://doi.org/10.1101/143552

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