Altered neocortical gene expression, brain overgrowth and functional over-connectivity in Chd8 haploinsufficient mice

Philipp Suetterlin; Shaun Hurley; Conor Mohan; Kimberley L. H. Riegman; Marco Pagani; Angela Caruso; Jacob Ellegood; Alberto Galbusera; Ivan Crespo-Enriquez; Caterina Michetti; Yohan Yee; Robert Ellingford; Olivier Brock; Alessio Delogu; Philippa Francis-West; Jason P. Lerch; Maria Luisa Scattoni; Alessandro Gozzi; Cathy Fernandes; M. Albert Basson

doi:10.1101/143552

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Altered neocortical gene expression, brain overgrowth and functional over-connectivity in Chd8 haploinsufficient mice

View ORCID ProfilePhilipp Suetterlin, Shaun Hurley, Conor Mohan, Kimberley L. H. Riegman, Marco Pagani, Angela Caruso, Jacob Ellegood, Alberto Galbusera, Ivan Crespo-Enriquez, Caterina Michetti, Yohan Yee, Robert Ellingford, Olivier Brock, Alessio Delogu, Philippa Francis-West, Jason P. Lerch, Maria Luisa Scattoni, Alessandro Gozzi, Cathy Fernandes, M. Albert Basson

doi: https://doi.org/10.1101/143552

Philipp Suetterlin

Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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ORCID record for Philipp Suetterlin

Shaun Hurley

Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Conor Mohan

Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Kimberley L. H. Riegman

Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Marco Pagani

Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, 38068 Rovereto, TN, Italy

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Angela Caruso

Neurotoxicology and Neuroendocrinology Section, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299,00161 Rome, ItalySchool of Behavioural Neuroscience, Department of Psychology, Sapienza University of Rome, via dei Marsi 78, 00185, Rome, Italy

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Jacob Ellegood

Department of Medical Biophysics, University of Toronto, Mouse Imaging Centre, Hospital for Sick Children, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada

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Alberto Galbusera

Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, 38068 Rovereto, TN, Italy

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Ivan Crespo-Enriquez

Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Caterina Michetti

Neurotoxicology and Neuroendocrinology Section, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299,00161 Rome, ItalyCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy

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Yohan Yee

Department of Medical Biophysics, University of Toronto, Mouse Imaging Centre, Hospital for Sick Children, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada

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Robert Ellingford

Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Olivier Brock

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK

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Alessio Delogu

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK

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Philippa Francis-West

Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UK

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Jason P. Lerch

Department of Medical Biophysics, University of Toronto, Mouse Imaging Centre, Hospital for Sick Children, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada

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Maria Luisa Scattoni

Neurotoxicology and Neuroendocrinology Section, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299,00161 Rome, Italy

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Alessandro Gozzi

Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, 38068 Rovereto, TN, Italy

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Cathy Fernandes

MRC Social, Genetic & Developmental Psychiatry Centre, PO82, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, London SE5 8AF, UKMRC Centre for Neurodevelopmental Disorders, King’s College London, 4th floor, New Hunt’s House, London SE1 1UL, UK

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M. Albert Basson

Department of Craniofacial Development and Stem Cell Biology, King’s College London, Floor 27, Guy’s Hospital Tower Wing, London, SE1 9RT, UKMRC Centre for Neurodevelopmental Disorders, King’s College London, 4th floor, New Hunt’s House, London SE1 1UL, UK

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For correspondence: albert.basson@kcl.ac.uk

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Table S1
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Table S11

Extended Data Table 2-1
Extended Data Tables 5-1 to 5-3
Extended Data Tables 5-4 to 5-9

Supplementary Table 1
Supplementary Tables 2-4
Supplementary Tables 5-10

Supplementary Table 1
Supplementary Tables 2-4
Supplementary Tables 5-10

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Posted February 27, 2018.

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Altered neocortical gene expression, brain overgrowth and functional over-connectivity in Chd8 haploinsufficient mice

Philipp Suetterlin, Shaun Hurley, Conor Mohan, Kimberley L. H. Riegman, Marco Pagani, Angela Caruso, Jacob Ellegood, Alberto Galbusera, Ivan Crespo-Enriquez, Caterina Michetti, Yohan Yee, Robert Ellingford, Olivier Brock, Alessio Delogu, Philippa Francis-West, Jason P. Lerch, Maria Luisa Scattoni, Alessandro Gozzi, Cathy Fernandes, M. Albert Basson

bioRxiv 143552; doi: https://doi.org/10.1101/143552

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