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Theta phase synchronization between the human hippocampus and the prefrontal cortex supports learning of unexpected information

View ORCID ProfileMatthias J. Gruber, Liang-Tien Hsieh, View ORCID ProfileBernhard P. Staresina, View ORCID ProfileChristian E. Elger, View ORCID ProfileJuergen Fell, View ORCID ProfileNikolai Axmacher, View ORCID ProfileCharan Ranganath
doi: https://doi.org/10.1101/144634
Matthias J. Gruber
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, UK
2Center for Neuroscience, UC Davis, USA
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Liang-Tien Hsieh
2Center for Neuroscience, UC Davis, USA
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Bernhard P. Staresina
3Department of Psychology, University of Birmingham, UK
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Christian E. Elger
4Department of Epileptology, University of Bonn, Germany
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Juergen Fell
4Department of Epileptology, University of Bonn, Germany
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Nikolai Axmacher
5Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Germany
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Charan Ranganath
2Center for Neuroscience, UC Davis, USA
6Department of Psychology, UC Davis, USA
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Abstract

Events that violate predictions are thought to not only modulate activity within the hippocampus and prefrontal cortex, but also to enhance communication between the two regions. Several studies in rodents have shown that synchronized theta oscillations facilitate communication between the prefrontal cortex and hippocampus during salient events, but it remains unclear whether similar oscillatory mechanisms support interactions between the two regions in humans. Here, we had the rare opportunity to conduct simultaneous electrophysiological recordings from the human hippocampus and prefrontal cortex from two patients undergoing presurgical evaluation for pharmaco-resistant epilepsy. Recordings were conducted during a task that involved encoding of contextually expected and unexpected visual stimuli. Across both patients, hippocampal-prefrontal theta phase synchronization was significantly higher during encoding of unexpected study items, compared to contextually expected study items. In contrast, we did not find increased theta synchronization between the prefrontal cortex and rhinal cortex. Our findings are consistent with the idea that theta oscillations orchestrate communication between the hippocampus and prefrontal cortex during the processing of contextually salient information.

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  • All authors do not have any conflict of interest to declare.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 31, 2017.
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Theta phase synchronization between the human hippocampus and the prefrontal cortex supports learning of unexpected information
Matthias J. Gruber, Liang-Tien Hsieh, Bernhard P. Staresina, Christian E. Elger, Juergen Fell, Nikolai Axmacher, Charan Ranganath
bioRxiv 144634; doi: https://doi.org/10.1101/144634
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Theta phase synchronization between the human hippocampus and the prefrontal cortex supports learning of unexpected information
Matthias J. Gruber, Liang-Tien Hsieh, Bernhard P. Staresina, Christian E. Elger, Juergen Fell, Nikolai Axmacher, Charan Ranganath
bioRxiv 144634; doi: https://doi.org/10.1101/144634

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