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A Cross-Sectional Study of Staphylococcus Aureus Colonization and the Nasal and Oropharyngeal Microbiomes

Ashley E. Kates, Mark Dalman, James C. Torner, Tara C. Smith
doi: https://doi.org/10.1101/145540
Ashley E. Kates
The University of Iowa, Iowa City, Iowa
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Mark Dalman
Kent State University, Kent, Ohio
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James C. Torner
The University of Iowa, Iowa City, Iowa
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Tara C. Smith
Kent State University, Kent, Ohio
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Abstract

Background Staphylococcus aureus is a frequent cause of both infections globally. Colonization with the organism is known to increase the risk of developing infections and occurs in roughly one third of the general population. While many factors influence colonization, it has been demonstrated other members of the microbiome influence colonization with S. aureus. Here, we assessed the nasal and oropharyngeal microbiomes of healthy participants in relation to S. aureus colonization in a cross-sectional study using 16s rRNA sequencing of the v1-v3 region. As livestock workers have also been shown to be at an increased risk of carriage, we have also assessed microbiota differences in colonization status in a population of livestock workers.

Results In both the nares and oropharynx, there were no microbiota differentially abundant between colonized and non-colonized persons. However, there was a significant difference in the beta diversity (Bray-Curtis distances) between carriers and non-carriers (P=0.002). When considering carriage stratified by livestock exposure, there were a number of differences. Most notably, colonized livestock workers had significantly more Porphyomonas (2-fold change = -8.54, P = 0.03) than the non-colonized livestock workers.

Conclusions S. aureus is a frequent colonizer of the human upper respiratory tract, including the nares and oropharynx and causes a wide range of infections. Livestock workers are at increased risk for carriage. Interventions such as improving oral hygiene may lead to decreased S. aureus carriage by reducing other bacterial species such as Porphyomonas. Larger, longitudinal studies are needed to better explore what microorganisms may be associated with S. aureus colonization.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 02, 2017.
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A Cross-Sectional Study of Staphylococcus Aureus Colonization and the Nasal and Oropharyngeal Microbiomes
Ashley E. Kates, Mark Dalman, James C. Torner, Tara C. Smith
bioRxiv 145540; doi: https://doi.org/10.1101/145540
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A Cross-Sectional Study of Staphylococcus Aureus Colonization and the Nasal and Oropharyngeal Microbiomes
Ashley E. Kates, Mark Dalman, James C. Torner, Tara C. Smith
bioRxiv 145540; doi: https://doi.org/10.1101/145540

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