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Multiple antibodies identify Glypican-1 on serum exosomes from patients with pancreatic cancer

Sonia Melo, Christoph Kahlert, Valerie LeBleu, Raghu Kalluri
doi: https://doi.org/10.1101/145706
Sonia Melo
1Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal (iI3S), 4200 Porto, Portugal
2Institute of Pathology and Molecular Immunology of the University of Porto (IPATIMUP), 4200 Porto, Portugal
3Medical School, Porto University (FMUP), 4200 Porto, Portugal
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Christoph Kahlert
4Department of Gastrointestinal, Thoracic and Vascular Surgery, Technische Universität Dresden, Germany
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Valerie LeBleu
5Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77005
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Raghu Kalluri
5Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77005
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Abstract

Glypican-1 was found on the surface of cancer exosomes using multiple antibodies from different sources. These include anti-GPC1 antibodies from ThermoFisher (PA5-28055 and PA-5-24972)1,2, Sigma (SAB270028), Abnova (MAB8351), EMD Millipore (MAB2600)3, SantaCruz4, and R&D Systems (BAF4519)2. Here we report on the specific detection of Glypican-1 on the exosomes derived from the serum of pancreas cancer patients using multiple antibodies.

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Posted June 08, 2017.
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Multiple antibodies identify Glypican-1 on serum exosomes from patients with pancreatic cancer
Sonia Melo, Christoph Kahlert, Valerie LeBleu, Raghu Kalluri
bioRxiv 145706; doi: https://doi.org/10.1101/145706
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Multiple antibodies identify Glypican-1 on serum exosomes from patients with pancreatic cancer
Sonia Melo, Christoph Kahlert, Valerie LeBleu, Raghu Kalluri
bioRxiv 145706; doi: https://doi.org/10.1101/145706

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