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The Gene Regulatory Landscape of Local Adaptation

Billie A. Gould, Yani Chen, David B. Lowry
doi: https://doi.org/10.1101/145805
Billie A. Gould
aDepartment of Plant Biology, Michigan State University, East Lansing, MI, USA
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Yani Chen
aDepartment of Plant Biology, Michigan State University, East Lansing, MI, USA
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David B. Lowry
aDepartment of Plant Biology, Michigan State University, East Lansing, MI, USA
bProgram in Ecology, Evolutionary Biology and Behavior, Michigan State University, East Lansing, MI 48824, USA
cPlant Resilience Institute, Michigan State University, East Lansing, MI 48824, USA
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Abstract

Local adaptation is a key driver of ecological specialization. Despite its importance, the evolution of gene regulatory divergence among locally-adapted populations is poorly understood. Here, we evaluate allele-specific gene expression responses for locally-adapted coastal and inland accessions of the plant Mimulus guttatus in a field reciprocal transplant experiment. We found 18% of transcripts were characterized by habitat-specific differential expression, a pattern consistent with the minimization of fitness trade-offs through expression plasticity. Cis-regulatory variation was pervasive, affecting 92% of differentially expressed genes. Chromosomal inversions were enriched for genes with expression divergence between ecotypes in a habitat-dependent manner, and gene expression heterosis was prevalent across habitats. These results provide multiple new insights into the evolution of transcriptome-wide gene regulatory divergence and plasticity among locally adapted populations.

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Posted June 03, 2017.
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The Gene Regulatory Landscape of Local Adaptation
Billie A. Gould, Yani Chen, David B. Lowry
bioRxiv 145805; doi: https://doi.org/10.1101/145805
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The Gene Regulatory Landscape of Local Adaptation
Billie A. Gould, Yani Chen, David B. Lowry
bioRxiv 145805; doi: https://doi.org/10.1101/145805

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