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Impairment of zebrafish reproduction upon exposure to melengestrol acetate

Kewen Xiong, Chunyun Zhong, Xin Wang
doi: https://doi.org/10.1101/146506
Kewen Xiong
Department of Environmental Toxicity, Third Hospital of Shanxi University
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Chunyun Zhong
Department of Environmental Toxicity, Third Hospital of Shanxi University
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Xin Wang
Department of Environmental Toxicity, Third Hospital of Shanxi University
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Abstract

Synthetic progestins contamination is common in the aquatic ecosystem, which may lead to serious health problem on aquatic animals. Melengestrol acetate (MGA) has been detected in the aquatic environment; however, its potential effects on fish reproduction are largely unclear. Here, we aimed to investigate the endocrine disruption and impact of MGA on zebrafish reproduction. Six-month old reproductive zebrafish were exposed to four nominal concentrations of MGA (1,10, 100 and 200 ng/L) for 15 days. Treatment with MGA reduced the egg production with a significant decrease at 200 ng/L. The circulating concentrations of estradiol and testosterone in female zebrafish or 11-keto testosterone in male zebrafish were significantly diminished compared to the non-exposed control fish. The early embryonic development or hatching rates were unaffected during the MGA exposure. Our results indicated that MGA was a potent endocrine disruptor in fish and the fish reproduction could be impaired even during a short-term exposure to MGA.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted June 06, 2017.
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Impairment of zebrafish reproduction upon exposure to melengestrol acetate
Kewen Xiong, Chunyun Zhong, Xin Wang
bioRxiv 146506; doi: https://doi.org/10.1101/146506
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Impairment of zebrafish reproduction upon exposure to melengestrol acetate
Kewen Xiong, Chunyun Zhong, Xin Wang
bioRxiv 146506; doi: https://doi.org/10.1101/146506

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