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Independent contributions of noradrenaline to behavioural flexibility and motivation

Caroline Jahn, Sophie Gilardeau, Chiara Varazzani, Bastien Blain, Jerome Sallet, Mark Walton, View ORCID ProfileSebastien Bouret
doi: https://doi.org/10.1101/147512
Caroline Jahn
1Motivation, Brain and Behavior Team, Institut du Cerveau et de la Moelle Epinière, 75013 Paris, France
2Frontières du Vivant, Université Sorbonne Paris Cité, Paris, France
3Department of Experimental Psychology, Oxford, OX1 3UD, United Kingdom
4Wellcome Centre for Integrative Neuroimaging, University of Oxford, UK
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Sophie Gilardeau
5Institute for Translational Neuroscience of Paris IHU-A-ICM, 75013 Paris, France
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Chiara Varazzani
1Motivation, Brain and Behavior Team, Institut du Cerveau et de la Moelle Epinière, 75013 Paris, France
2Frontières du Vivant, Université Sorbonne Paris Cité, Paris, France
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Bastien Blain
1Motivation, Brain and Behavior Team, Institut du Cerveau et de la Moelle Epinière, 75013 Paris, France
6Centre d’Economie de la Sorbonne, Université Paris 1, 75013 Paris, France
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Jerome Sallet
3Department of Experimental Psychology, Oxford, OX1 3UD, United Kingdom
4Wellcome Centre for Integrative Neuroimaging, University of Oxford, UK
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Mark Walton
3Department of Experimental Psychology, Oxford, OX1 3UD, United Kingdom
4Wellcome Centre for Integrative Neuroimaging, University of Oxford, UK
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Sebastien Bouret
1Motivation, Brain and Behavior Team, Institut du Cerveau et de la Moelle Epinière, 75013 Paris, France
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  • ORCID record for Sebastien Bouret
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Abstract

Among neuromodulatory systems, the noradrenergic system remains one of the least understood. Several theories have pointed out its implication in behavioural flexibility and more recently in motivation, with a strong role in effort processing. Here, we designed a sequential cost/benefit decision task to test the causal role of noradrenaline in these two functions. We manipulated noradrenaline using clonidine, an alpha-2 noradrenergic receptor agonist, which reduces central noradrenaline levels. Clonidine had two distinct effects: it decreased choice volatility (without affecting the cost/benefit trade off) and reduced force production. Because the effects were independent, they cannot be accounted for by a non-specific effect on arousal. Altogether, these results support the global implication of noradrenaline in facing challenging situations in two complementary ways: by modulating behavioural volatility, which would facilitate adaptation depending on the lability of the environment, and by modulating the mobilization of resources to face immediate challenges.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 08, 2017.
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Independent contributions of noradrenaline to behavioural flexibility and motivation
Caroline Jahn, Sophie Gilardeau, Chiara Varazzani, Bastien Blain, Jerome Sallet, Mark Walton, Sebastien Bouret
bioRxiv 147512; doi: https://doi.org/10.1101/147512
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Independent contributions of noradrenaline to behavioural flexibility and motivation
Caroline Jahn, Sophie Gilardeau, Chiara Varazzani, Bastien Blain, Jerome Sallet, Mark Walton, Sebastien Bouret
bioRxiv 147512; doi: https://doi.org/10.1101/147512

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