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Intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly

David S. W. Protter, Bhalchandra S. Rao, Briana Van Treeck, Yuan Lin, Laura Mizoue, View ORCID ProfileMichael K. Rosen, View ORCID ProfileRoy Parker
doi: https://doi.org/10.1101/147561
David S. W. Protter
1Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA
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Bhalchandra S. Rao
1Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA
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Briana Van Treeck
1Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA
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Yuan Lin
2Department of Biophysics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
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Laura Mizoue
1Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA
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Michael K. Rosen
2Department of Biophysics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
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  • ORCID record for Michael K. Rosen
Roy Parker
1Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA
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  • ORCID record for Roy Parker
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Abstract

Eukaryotic cells contain large RNA-protein assemblies referred to as RNP granules, whose assembly is promoted by both traditional protein interactions and intrinsically disordered protein domains. Using RNP granules as an example, we provide evidence for an assembly mechanism of large cellular structures wherein specific protein-protein or protein-RNA interactions act together with promiscuous interactions of intrinsically disordered regions (IDRs). This synergistic assembly mechanism illuminates RNP granule assembly, and explains why many components of RNP granules, and other large dynamic assemblies, contain IDRs linked to specific protein-protein or protein-RNA interaction modules. We suggest assemblies based on combinations of specific interactions and promiscuous IDRs are common features of eukaryotic cells.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted June 13, 2017.
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Intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly
David S. W. Protter, Bhalchandra S. Rao, Briana Van Treeck, Yuan Lin, Laura Mizoue, Michael K. Rosen, Roy Parker
bioRxiv 147561; doi: https://doi.org/10.1101/147561
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Intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly
David S. W. Protter, Bhalchandra S. Rao, Briana Van Treeck, Yuan Lin, Laura Mizoue, Michael K. Rosen, Roy Parker
bioRxiv 147561; doi: https://doi.org/10.1101/147561

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