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Magnetic entropy as a gating mechanism for magnetogenetic ion channels

Guillaume Duret, Sruthi Polali, Erin D. Anderson, A. Martin Bell, Constantine N. Tzouanas, Benjamin W. Avants, View ORCID ProfileJacob T. Robinson
doi: https://doi.org/10.1101/148379
Guillaume Duret
1Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX, 77005
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Sruthi Polali
1Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX, 77005
3Applied Physics Program, Rice University, 6100 Main Street, Houston, TX, 77005
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Erin D. Anderson
2Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005
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A. Martin Bell
1Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX, 77005
3Applied Physics Program, Rice University, 6100 Main Street, Houston, TX, 77005
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Constantine N. Tzouanas
2Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005
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Benjamin W. Avants
1Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX, 77005
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Jacob T. Robinson
1Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX, 77005
4Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030
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  • ORCID record for Jacob T. Robinson
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Abstract

Magnetically sensitive ion channels would allow researchers to better study how specific brain cells affect behavior in freely moving animals; however, recent reports of “magnetogenetic” ion channels have been questioned because known biophysical mechanisms cannot explain experimental observations. Here we show that magnetic fields can produce a change in the magnetic entropy of biogenic nanoparticles, which in turn may generate sufficient heat to gate temperature-sensitive ion channels. This magnetocaloric effect provides a rational approach for developing future magnetogenetic channels.

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Posted June 23, 2017.
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Magnetic entropy as a gating mechanism for magnetogenetic ion channels
Guillaume Duret, Sruthi Polali, Erin D. Anderson, A. Martin Bell, Constantine N. Tzouanas, Benjamin W. Avants, Jacob T. Robinson
bioRxiv 148379; doi: https://doi.org/10.1101/148379
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Magnetic entropy as a gating mechanism for magnetogenetic ion channels
Guillaume Duret, Sruthi Polali, Erin D. Anderson, A. Martin Bell, Constantine N. Tzouanas, Benjamin W. Avants, Jacob T. Robinson
bioRxiv 148379; doi: https://doi.org/10.1101/148379

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