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Differing strategies used by motor neurons and glia to achieve robust development of an adult neuropil in Drosophila

Jonathan Enriquez, Laura Quintana Rio, Richard Blazeski, Carol Mason, Richard S. Mann
doi: https://doi.org/10.1101/149229
Jonathan Enriquez
Institut de Génomique Fonctionnelle de Lyon, ENS de Lyon, CNRS, Univ Lyon 1, 46 Allée d′Italie, 69364 Lyon cedex 07, France
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Laura Quintana Rio
Departments of Biochemistry and Molecular Biophysics, and Neuroscience, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA
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Richard Blazeski
Departments of Pathology and Cell Biology, and Neuroscience, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA
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Carol Mason
Departments of Pathology and Cell Biology, and Neuroscience, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA
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Richard S. Mann
Departments of Biochemistry and Molecular Biophysics, and Neuroscience, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA
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Summary

In both vertebrates and invertebrates, neurons and glia are generated in a stereotyped order from dedicated progenitors called neural stem cells, but the purpose of invariant lineages is not understood. Here we show that three of the stem cells that produce leg motor neurons in Drosophila also generate a specialized subset of glia, the neuropil glia, which wrap and send processes into the neuropil where motor neuron dendrites arborize. The development of the neuropil glia and leg motor neurons is highly coordinated. However, although individual motor neurons have a stereotyped birth order and transcription factor code, both the number and individual morphologies of the glia born from these lineages are highly plastic, even though the final structure they contribute to is highly stereotyped. We suggest that the shared lineages of these two cell types facilitates the assembly of complex neural circuits, and that the two different birth order strategies – hardwired for motor neurons and flexible for glia – are important for robust nervous system development and homeostasis.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 13, 2017.
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Differing strategies used by motor neurons and glia to achieve robust development of an adult neuropil in Drosophila
Jonathan Enriquez, Laura Quintana Rio, Richard Blazeski, Carol Mason, Richard S. Mann
bioRxiv 149229; doi: https://doi.org/10.1101/149229
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Differing strategies used by motor neurons and glia to achieve robust development of an adult neuropil in Drosophila
Jonathan Enriquez, Laura Quintana Rio, Richard Blazeski, Carol Mason, Richard S. Mann
bioRxiv 149229; doi: https://doi.org/10.1101/149229

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