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Pericyte ontogeny: the use of chimeras to track a cell lineage of diverse germ line origins

View ORCID ProfileHeather C. Etchevers
doi: https://doi.org/10.1101/149922
Heather C. Etchevers
Aix Marseille Univ, INSERM, UMR_S910, GMGF, Marseille, France
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Abstract

The goal of lineage tracing is to understand body formation over time by discovering which cells are the progeny of a specific, identified, ancestral progenitor. Subsidiary questions include unequivocal identification of what they have become, how many descendants develop, whether they live or die, and where they are located in the tissue or body at the end of the window examined. A classical approach in experimental embryology, lineage tracing continues to be used in developmental biology, stem cell and cancer research, wherever cellular potential and behavior need to be studied in multiple dimensions, of which one is time. Each technical approach has its advantages and drawbacks. This chapter, with some previously unpublished data, will concentrate non-exclusively on the use of interspecies chimeras to explore the origins of perivascular (or mural) cells, of which those adjacent to the vascular endothelium are termed pericytes for this purpose. These studies laid the groundwork for our understanding that pericytes derive from progenitor mesenchymal pools of multiple origins in the vertebrate embryo, some of which persist into adulthood. The results obtained through xenografting, like in the methodology described here, complement those obtained through genetic lineage tracing techniques within a given species.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 16, 2018.
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Pericyte ontogeny: the use of chimeras to track a cell lineage of diverse germ line origins
Heather C. Etchevers
bioRxiv 149922; doi: https://doi.org/10.1101/149922
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Pericyte ontogeny: the use of chimeras to track a cell lineage of diverse germ line origins
Heather C. Etchevers
bioRxiv 149922; doi: https://doi.org/10.1101/149922

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