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A dementia-associated risk variant near TMEM106B alters chromatin architecture and gene expression

Michael D. Gallagher, Marijan Posavi, Peng Huang, Travis L. Unger, Yosef Berlyand, Analise L. Gruenewald, Alessandra Chesi, Elisabetta Manduchi, Andrew D. Wells, Struan F.A. Grant, Gerd A. Blobel, Christopher D. Brown, View ORCID ProfileAlice S. Chen-Plotkin
doi: https://doi.org/10.1101/154989
Michael D. Gallagher
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Marijan Posavi
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Peng Huang
2Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
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Travis L. Unger
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Yosef Berlyand
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Analise L. Gruenewald
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Alessandra Chesi
3Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
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Elisabetta Manduchi
3Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
4Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA
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Andrew D. Wells
5Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Struan F.A. Grant
2Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
3Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
6Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA
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Gerd A. Blobel
2Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
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Christopher D. Brown
6Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA
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Alice S. Chen-Plotkin
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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  • ORCID record for Alice S. Chen-Plotkin
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Article Information

doi 
https://doi.org/10.1101/154989
History 
  • June 24, 2017.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Michael D. Gallagher1,
  2. Marijan Posavi1,
  3. Peng Huang2,
  4. Travis L. Unger1,
  5. Yosef Berlyand1,
  6. Analise L. Gruenewald1,
  7. Alessandra Chesi3,
  8. Elisabetta Manduchi3,4,
  9. Andrew D. Wells5,
  10. Struan F.A. Grant2,3,6,
  11. Gerd A. Blobel2,
  12. Christopher D. Brown6 and
  13. Alice S. Chen-Plotkin1
  1. 1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
  2. 2Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
  3. 3Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
  4. 4Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA
  5. 5Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
  6. 6Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA
  1. Correspondence: Alice S. Chen-Plotkin, Department of Neurology, 3 W Gates, 3400 Spruce St, Philadelphia, PA 19104, Email: chenplot{at}mail.med.upenn.edu, Telephone: 215-573-7193 Fax: 215-829-6606
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A dementia-associated risk variant near TMEM106B alters chromatin architecture and gene expression
Michael D. Gallagher, Marijan Posavi, Peng Huang, Travis L. Unger, Yosef Berlyand, Analise L. Gruenewald, Alessandra Chesi, Elisabetta Manduchi, Andrew D. Wells, Struan F.A. Grant, Gerd A. Blobel, Christopher D. Brown, Alice S. Chen-Plotkin
bioRxiv 154989; doi: https://doi.org/10.1101/154989
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A dementia-associated risk variant near TMEM106B alters chromatin architecture and gene expression
Michael D. Gallagher, Marijan Posavi, Peng Huang, Travis L. Unger, Yosef Berlyand, Analise L. Gruenewald, Alessandra Chesi, Elisabetta Manduchi, Andrew D. Wells, Struan F.A. Grant, Gerd A. Blobel, Christopher D. Brown, Alice S. Chen-Plotkin
bioRxiv 154989; doi: https://doi.org/10.1101/154989

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