Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation

View ORCID ProfileValdas Noreika, Marc R. Kamke, Andrés Canales-Johnson, View ORCID ProfileSrivas Chennu, Tristan A. Bekinschtein, View ORCID ProfileJason B. Mattingley
doi: https://doi.org/10.1101/155754
Valdas Noreika
1Queensland Brain Institute, University of Queensland, St Lucia, QLD 4072, Australia
2Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Valdas Noreika
  • For correspondence: vn261@cam.ac.uk
Marc R. Kamke
1Queensland Brain Institute, University of Queensland, St Lucia, QLD 4072, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrés Canales-Johnson
2Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Srivas Chennu
3School of Computing, University of Kent, Medway, United Kingdom
4Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Srivas Chennu
Tristan A. Bekinschtein
2Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jason B. Mattingley
1Queensland Brain Institute, University of Queensland, St Lucia, QLD 4072, Australia
5School of Psychology, University of Queensland, St Lucia, QLD 4072, Australia
6Canadian Institute for Advanced Research (CIFAR)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jason B. Mattingley
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

ABSTRACT

Transcranial magnetic stimulation (TMS) has been widely used in human cognitive neuroscience to examine the causal role of distinct cortical areas in perceptual, cognitive and motor functions. However, it is widely acknowledged that the effects of focal cortical stimulation on behaviour can vary substantially between participants and even from trial to trial within individuals. Here we asked whether spontaneous fluctuations in alertness can account for the variability in behavioural and neurophysiological responses to TMS. We combined single-pulse TMS with neural recording via electroencephalography (EEG) to quantify changes in motor and cortical reactivity with fluctuating levels of alertness defined objectively on the basis of ongoing brain activity. We observed rapid, non-linear changes in TMS-evoked neural responses – specifically, motor evoked potentials and TMS-evoked cortical potentials – as EEG activity indicated decreasing levels of alertness, even while participants remained awake and responsive in the behavioural task.

IMPACT STATEMENT A substantial proportion of inter-trial variability in neurophysiological responses to TMS is due to spontaneous fluctuations in alertness, which should be controlled for during experimental and clinical applications of TMS.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted June 28, 2019.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation
Valdas Noreika, Marc R. Kamke, Andrés Canales-Johnson, Srivas Chennu, Tristan A. Bekinschtein, Jason B. Mattingley
bioRxiv 155754; doi: https://doi.org/10.1101/155754
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation
Valdas Noreika, Marc R. Kamke, Andrés Canales-Johnson, Srivas Chennu, Tristan A. Bekinschtein, Jason B. Mattingley
bioRxiv 155754; doi: https://doi.org/10.1101/155754

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4397)
  • Biochemistry (9619)
  • Bioengineering (7114)
  • Bioinformatics (24917)
  • Biophysics (12644)
  • Cancer Biology (9982)
  • Cell Biology (14390)
  • Clinical Trials (138)
  • Developmental Biology (7981)
  • Ecology (12136)
  • Epidemiology (2067)
  • Evolutionary Biology (16012)
  • Genetics (10941)
  • Genomics (14768)
  • Immunology (9891)
  • Microbiology (23720)
  • Molecular Biology (9495)
  • Neuroscience (51027)
  • Paleontology (370)
  • Pathology (1544)
  • Pharmacology and Toxicology (2688)
  • Physiology (4031)
  • Plant Biology (8687)
  • Scientific Communication and Education (1512)
  • Synthetic Biology (2403)
  • Systems Biology (6450)
  • Zoology (1346)