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Human-specific changes in two functional enhancers of FOXP2

Antonio Benítez-Burraco, Raúl Torres-Ruiz, Pere Gelabert Xirinachs, Carles Lalueza-Fox, Sandra Rodríguez-Perales, Paloma García-Bellido
doi: https://doi.org/10.1101/157016
Antonio Benítez-Burraco
1Department of Philology, University of Huelva, Huelva, Spain.
2Faculty of Modern Languages, University of Oxford, Oxford, United Kingdom.
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  • For correspondence: antonio.benitez@dfesp.uhu.es
Raúl Torres-Ruiz
3Molecular Cytogenetics Group. Centro Nacional Investigaciones Oncológicas (CNIO), Madrid, Spain.
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Pere Gelabert Xirinachs
4Paleogenomics Lab, Institute of Evolutionary Biology. CSIC/Pompeu Fabra University, Barcelona, Spain.
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Carles Lalueza-Fox
4Paleogenomics Lab, Institute of Evolutionary Biology. CSIC/Pompeu Fabra University, Barcelona, Spain.
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Sandra Rodríguez-Perales
3Molecular Cytogenetics Group. Centro Nacional Investigaciones Oncológicas (CNIO), Madrid, Spain.
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Paloma García-Bellido
2Faculty of Modern Languages, University of Oxford, Oxford, United Kingdom.
5Faculty of Linguistics, Philology and Phonetics, University of Oxford, Oxford, United Kingdom.
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Abstract

Two functional enhancers of FOXP2, a gene important for language development and evolution, exhibit several human-specific changes compared to extinct hominins that are located within the binding site for different transcription factors. Specifically, Neanderthals and Denisovans bear the ancestral allele in one position within the binding site for SMARCC1, involved in brain development and vitamin D metabolism. This change might have resulted in a different pattern of FOXP2 expression in our species compared to extinct hominins.

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Posted June 28, 2017.
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Human-specific changes in two functional enhancers of FOXP2
Antonio Benítez-Burraco, Raúl Torres-Ruiz, Pere Gelabert Xirinachs, Carles Lalueza-Fox, Sandra Rodríguez-Perales, Paloma García-Bellido
bioRxiv 157016; doi: https://doi.org/10.1101/157016
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Human-specific changes in two functional enhancers of FOXP2
Antonio Benítez-Burraco, Raúl Torres-Ruiz, Pere Gelabert Xirinachs, Carles Lalueza-Fox, Sandra Rodríguez-Perales, Paloma García-Bellido
bioRxiv 157016; doi: https://doi.org/10.1101/157016

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