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Does human primary motor cortex represent sequences of finger movements?

View ORCID ProfileAtsushi Yokoi, Spencer A. Arbuckle, View ORCID ProfileJörn Diedrichsen
doi: https://doi.org/10.1101/157438
Atsushi Yokoi
1The Brain and Mind Institute, University of Western Ontario, Canada
2Graduate School of Frontier Biosciences, Osaka University, Japan
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Spencer A. Arbuckle
1The Brain and Mind Institute, University of Western Ontario, Canada
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Jörn Diedrichsen
1The Brain and Mind Institute, University of Western Ontario, Canada
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Abstract

Human primary motor cortex (M1) is an essential structure for the production of dexterous hand movements. While distinct sub-populations of neurons are activated during single finger movements, it remains unknown whether M1 also represents sequences of multiple finger movements. Using novel multivariate fMRI analysis techniques, we show here that even after 5 days of intense practice there was little or no evidence for a true sequence representation in M1. Rather, the activity patterns for sequences in M1 could be explained by linear combination of patterns associated with the constituent individual finger movements, with the strongest weight on the finger making the first response of the sequence. These results suggest that M1 only represents single finger movements, but receives increased input at the start of a sequence. In contrast, the reliable differences between different sequences in premotor and parietal areas could not be explained by a strong weighting of the first finger, supporting the view that these regions exhibit a true representation of sequences.

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Posted June 29, 2017.
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Does human primary motor cortex represent sequences of finger movements?
Atsushi Yokoi, Spencer A. Arbuckle, Jörn Diedrichsen
bioRxiv 157438; doi: https://doi.org/10.1101/157438
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Does human primary motor cortex represent sequences of finger movements?
Atsushi Yokoi, Spencer A. Arbuckle, Jörn Diedrichsen
bioRxiv 157438; doi: https://doi.org/10.1101/157438

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