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Pivot-and-bond model explains microtubule bundle formation

Marcel Prelogović, Lora Winters, Ana Milas, Iva M. Tolić, Nenad Pavin
doi: https://doi.org/10.1101/157719
Marcel Prelogović
1Department of Physics, Faculty of Science, University of Zagreb, Bijenička cesta 32, 10000 Zagreb, Croatia
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Lora Winters
2Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany
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Ana Milas
3Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia
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Iva M. Tolić
2Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany
3Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia
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  • For correspondence: npavin@phy.hr tolic@irb.hr
Nenad Pavin
1Department of Physics, Faculty of Science, University of Zagreb, Bijenička cesta 32, 10000 Zagreb, Croatia
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  • For correspondence: npavin@phy.hr tolic@irb.hr
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ABSTRACT

During mitosis, bundles of microtubules form a spindle, but the physical mechanism of bundle formation is still not known. Here we show that random angular movement of microtubules around the spindle pole and forces exerted by passive cross-linking proteins are sufficient for the formation of stable microtubule bundles. We test these predictions by experiments in wild-type and ase1Δ fission yeast cells. In conclusion, the angular motion drives the alignment of microtubules, which in turn allows the cross-linking proteins to connect the microtubules into a stable bundle.

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Posted August 20, 2017.
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Pivot-and-bond model explains microtubule bundle formation
Marcel Prelogović, Lora Winters, Ana Milas, Iva M. Tolić, Nenad Pavin
bioRxiv 157719; doi: https://doi.org/10.1101/157719
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Pivot-and-bond model explains microtubule bundle formation
Marcel Prelogović, Lora Winters, Ana Milas, Iva M. Tolić, Nenad Pavin
bioRxiv 157719; doi: https://doi.org/10.1101/157719

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