New Results
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy
Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver, Moira M. Welch, Lucas B. Harrington, Samuel H. Sternberg, J. Keith Joung, Ahmet Yildiz, Jennifer A. Doudna
doi: https://doi.org/10.1101/160036
Janice S. Chen
1Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, 11 USA.
Yavuz S. Dagdas
2Biophysics Graduate Group, University of California, Berkeley, California 94720, USA.
Benjamin P. Kleinstiver
3Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
4Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Moira M. Welch
3Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
Lucas B. Harrington
1Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, 11 USA.
Samuel H. Sternberg
5Department of Chemistry, University of California, Berkeley, California 94720, USA.
J. Keith Joung
3Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
4Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Ahmet Yildiz
1Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, 11 USA.
6Department of Physics, University of California, Berkeley, California 94720, USA.
Jennifer A. Doudna
1Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, 11 USA.
5Department of Chemistry, University of California, Berkeley, California 94720, USA.
7Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA.
8Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Article usage
Posted July 06, 2017.
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy
Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver, Moira M. Welch, Lucas B. Harrington, Samuel H. Sternberg, J. Keith Joung, Ahmet Yildiz, Jennifer A. Doudna
bioRxiv 160036; doi: https://doi.org/10.1101/160036
Subject Area
Subject Areas
- Biochemistry (13735)
- Bioengineering (10463)
- Bioinformatics (33242)
- Biophysics (17149)
- Cancer Biology (14214)
- Cell Biology (20142)
- Clinical Trials (138)
- Developmental Biology (10885)
- Ecology (16059)
- Epidemiology (2067)
- Evolutionary Biology (20377)
- Genetics (13424)
- Genomics (18666)
- Immunology (13794)
- Microbiology (32214)
- Molecular Biology (13406)
- Neuroscience (70180)
- Paleontology (527)
- Pathology (2199)
- Pharmacology and Toxicology (3748)
- Physiology (5890)
- Plant Biology (12037)
- Synthetic Biology (3373)
- Systems Biology (8177)
- Zoology (1845)